Results 81 to 90 of about 44,755 (204)

Pharmacotherapy of von Willebrand disease

, 2013
Introduction: Von Willebrand disease (VWD), the most common inherited bleeding disorder, is typically due to quantitative or qualitative deficiencies of von Willebrand factor (VWF).Areas covered: This review, which also summarizes the clinical ...
Franchini, Massimo, Lippi, Giuseppe
core   +1 more source

Aortic Stenosis and Acquired von Willebrand Disease: Lack of Association

, 2011
Objectives: The association between aortic stenosis (AS) and acquired von Willebrand disease type 2A has been described. It may be present in up to 90% of patients with AS.
Zalaquett, Ricardo, Ricardo Zalaquett, Rodrigo López, Rattalino, Marcos, Pereira, Jaime, Claudia Carvajal, Lema, Guillermo, Carvajal, Claudia, Lopez, Rodrigo, Jaime Pereira, Guillermo Lema, Marcos Rattalino, Paulo Carrasco, Carrasco, Paulo, Esperanza Carrasco, Roberto Canessa, Carrasco, Esperanza, Canessa, Roberto   +17 more
core   +1 more source

Recent advances in the diagnosis of von Willebrand disease

LabMed Discovery
Von Willebrand disease (VWD) is caused by a quantitative or qualitative defect of von Willebrand factor (VWF). Despite its prevalence as the most common hereditary bleeding disorder and the associated morbidity, its diagnosis and classification remains a
Qian Liang, Renhao Li
doaj   +1 more source

Exposure–Response Relationship between VWF/FVIII Activity and Spontaneous Bleeding Events Following Recombinant VWF Prophylaxis in Severe VWD

TH Open
Background Recombinant von Willebrand factor (rVWF, vonicog alfa, Takeda Pharmaceuticals USA) is indicated in adults diagnosed with von Willebrand disease (VWD).
Frank W.G. Leebeek, Giancarlo Castaman, Jean François Marier, Gülden Özen, Indranil Bhattacharya, Jingmei Zhang, Scarlett Wang, Yi Wang   +7 more
doaj   +1 more source

Decreased plasma ADAMTS-13 activity as a predictor of postoperative bleeding in cyanotic congenital heart disease

Clinics, 2013
OBJECTIVE: To analyze the preoperative plasma antigenic concentration and activity of von Willebrand factor and its main cleaving protease ADAMTS-13 in pediatric patients with cyanotic congenital heart disease undergoing surgical treatment and ...
Rosangela P.S. Soares, Sérgio P. Bydlowski, Marcelo B. Jatene, Janete Ferreira Hironaka, Antonio Augusto Lopes   +4 more
doaj  

Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

Bleeding, Thrombosis and Vascular Biology
Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative and/or qualitative defects of von Willebrand factor (VWF), a multimeric glycoprotein synthesized by endothelial cells and megakaryocytes. VWF plays a crucial role in hemostasis by
Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro   +7 more
doaj   +1 more source

The elusive and heterogeneous pattern of type 2M von Willebrand disease: A diagnostic challenge

, 2018
Type 2M is a very heterogeneous form of von Willebrand disease (VWD) associated with impaired platelet and von Willebrand factor (VWF) interactions not due to a lack of large VWF ...
Casonato, Alessandra, Viviana Daidone, Daidone, Viviana, Alessandra Casonato, Galletta, Eva, Eva Galletta   +5 more
core   +1 more source

Unexpected massive bleeding during the modified LeFort III advancement surgery for Crouzon syndrome: A case report

Clinical Case Reports
Key Clinical Message Vigilant monitoring for postoperative complications, including bleeding and dysrhythmia, is crucial in patients with craniosynostosis syndromes like Crouzon syndrome undergoing craniofacial surgery, with a thorough evaluation ...
Zahra Sadat Modarresi, Narges Hajiani, Zeinab Bakhtiari, Farnoush Mohammadi   +3 more
doaj   +1 more source

Intravenous Immunoglobulin offers temporary improvement in acquired von Willebrand syndrome due to monoclonal gammopathy: A case report

eJHaem
Acquired von Willebrand syndrome (AVWS) is a bleeding disorder in which an underlying condition induces a quantitative or qualitative deficiency in the von Willebrand factor.
Kevin G. Zablonski, Aarthi Rajkumar, Lalitha Nayak   +2 more
doaj   +1 more source

Von Willebrand disease [PDF]

Clinical Medicine, 2007
openaire   +2 more sources