In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability [PDF]
, 2016 Endothelial cells (ECs) form the inner layer of blood vessels and physically separate the blood from the surrounding tissue. To support tissues with nutrients and oxygen, the endothelial monolayer is semipermeable.
Anderson, Kurt I. +7 more
core +10 more sources
Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities
Arthritis &Rheumatology, EarlyView.Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley +1 more source
Correlation of intracardiac hemodynamics indicators with von Willebrand factor – Marker of endothelial dysfunction in patients with coronary artery disease combined with coronavirus disease (COVID-19) [PDF]
Българска кардиологияThe research relevance is predefined by the need to establish the relationship and identify new markers and potential contributions to clinical practice and scientific progress.
V. Netiazhenko, S. Mostovyi, O. Safonova
doaj +3 more sources
Haemophilia A and von Willebrand’s disease [PDF]
Haemophilia, 2010 Summary. Deficient or defective coagulation factor VIII (FVIII) and von Willebrand factor (VWF) can cause bleeding through congenital deficiency or acquired inhibitory antibodies. Recent studies on type 1 von Willebrand’s disease (VWD), the most common form of the disease, have begun to explain its pathogenesis.
Goodeve, A.C., Rosen, S., Verbruggen, B.
openaire +4 more sources
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background The quality of saphenous vein (SV) grafts can vary depending on the site from which they are harvested. However, few studies have compared SV grafts harvested from the thigh with those harvested from the calf to explore which is more appropriate for use in coronary artery bypass grafting (CABG). In this study, we evaluated the graft
Aidong Chen, Ke Pan
wiley +1 more source
von Willebrand Disease: The diagnosis and management of this bleeding disorder
Medical Journal of Babylon, 2020 von Willebrand disease (vWD) is one of the most common bleeding disorders, first described by Erik von Willebrand in the Aland Islands. It occurs as a result of decreased or abnormal von Willebrand factor (vWF), a factor that is needed in the process of ...
Basim A. Abd, Nawrass J Al-Salihi
doaj +1 more source
Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]
, 2009 The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Bõze, Tamás +9 more
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source
Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease. [PDF]
PLoS ONE, 2016 Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors.
Alessandra Casonato +5 more
doaj +1 more source
Prophylaxis in von Willebrand Disease: Coming of Age? [PDF]
, 2016 Although in most cases von Willebrand disease (VWD) is a mild disorder, a subgroup of patients experience frequent bleeding. In contrast to severe hemophilia in which prophylaxis is the accepted standard of care, this is less frequently used in VWD. Most
Makris, M., Saccullo, G.
core +1 more source