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JAMA: The Journal of the American Medical Association, 1971
Von Willebrand's disease is a familial hemorrhagic condition. There is no single test for diagnosis, no agreement on the pathogenesis, and no evidence as to the genetics of inheritance. Seven abnormalities have been reported to characterize the disease: prolonged bleeding time, capillary abnormality, thrombocytopathy, reduced blood-clotting factor VIII
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Von Willebrand's disease is a familial hemorrhagic condition. There is no single test for diagnosis, no agreement on the pathogenesis, and no evidence as to the genetics of inheritance. Seven abnormalities have been reported to characterize the disease: prolonged bleeding time, capillary abnormality, thrombocytopathy, reduced blood-clotting factor VIII
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von Willebrand Disease and Pregnancy
Journal of Maternal-Fetal and Neonatal Medicine, 2000von Willebrand Disease (vWD) affects approximately 1% of Americans and as many as 25% of women referred for evaluation of menorrhagia. We briefly review the history of vWD, its molecular defects, and diagnostic criteria for each subtype of disease. We also address obstetric management of the patient with vWD. While there is a significant increased risk
Edmund F. Funai +2 more
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Nature Reviews Disease Primers
von Willebrand disease (VWD) is the most common inherited bleeding disorder. The disorder is characterized by excessive mucocutaneous bleeding. The most common bleeding manifestations of this condition include nosebleeds, bruising, bleeding from minor wounds, menorrhagia or postpartum bleeding in women as well as bleeding after surgery.
Omid Seidizadeh +9 more
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von Willebrand disease (VWD) is the most common inherited bleeding disorder. The disorder is characterized by excessive mucocutaneous bleeding. The most common bleeding manifestations of this condition include nosebleeds, bruising, bleeding from minor wounds, menorrhagia or postpartum bleeding in women as well as bleeding after surgery.
Omid Seidizadeh +9 more
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Diagnosis of von Willebrand Disease
Haemophilia, 1999The haemorrhagic diathesis in von Willebrand disease (vWD) is caused by a quantitative deficiency or a qualitative defect in the von Willebrand factor (vWF) in plasma and/or platelets causing insufficient primary haemostasis. Since vWF binds and protects factor VIII (FVIII) towards random proteolysis, coagulation may also be impaired in patients with a
Ingerslev, J, Gursel, T
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Hematology/Oncology Clinics of North America, 1990
The study of a wide variety of patients with vWD disorders has been extensive and intense over the last decade. In many instances the peculiarities of the expressions of the disorder have been critical in defining the underlying structure and function of vWF itself.
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The study of a wide variety of patients with vWD disorders has been extensive and intense over the last decade. In many instances the peculiarities of the expressions of the disorder have been critical in defining the underlying structure and function of vWF itself.
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von Willebrand factor and von Willebrand disease.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2016von Willebrand factor (VWF) has two major roles in hemostasis, as a form of molecular glue which functions in platelet plug formation and as a protective transporter for coagulation factor VIII (FVIII). VWF shows a multimeric chain structure composed of 270 kDa subunits containing binding domains for FVIII, platelet and collagens. Biosynthesis, storage,
Jiharu Hamako, Taei Matsui
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Postgraduate Medicine, 1980
Von Willebrand's disease is an autosomally transmitted disorder of hemostasis caused by a deficiency of or defect in the von Willebrand factor in the blood, a protein required for adherence of platelets to an injured vessel wall. The disease's principal manifestations are spontaneous bleeding from mucous membranes, excessive bleeding from wounds, and ...
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Von Willebrand's disease is an autosomally transmitted disorder of hemostasis caused by a deficiency of or defect in the von Willebrand factor in the blood, a protein required for adherence of platelets to an injured vessel wall. The disease's principal manifestations are spontaneous bleeding from mucous membranes, excessive bleeding from wounds, and ...
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Acquired von Willebrand Disease
Mayo Clinic Proceedings, 2002Acquired von Willebrand disease (AvWD) is a relatively rare acquired bleeding disorder that usually occurs in elderly patients, in whom its recognition may be delayed. Patients usually present predominantly with mucocutaneous bleeding, with no previous history of bleeding abnormalities and no clinically meaningful family history.
William L. Nichols +2 more
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Treatment of von Willebrand's disease
Journal of Internal Medicine, 1997von Willebrand's disease is the most frequent of inherited bleeding disorders (1:100 affected individuals in the general population). The aim of therapy is to correct the dual defects of haemostasis, i.e. abnormal coagulation expressed by low levels of factor VIII and abnormal platelet adhesion expressed by a prolonged bleeding time. There are two main
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2018
Von Willebrand disease (vWD) is the most common bleeding disorder in humans. It is the result of an abnormality in the amount, structure, or function of von Willebrand factor (vWF), a glycoprotein important in maintaining normal hemostasis.. In children with vWD, the most frequent presentation is easy bruising and epistaxis.
Nina A. Guzzetta, Laura A. Downey
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Von Willebrand disease (vWD) is the most common bleeding disorder in humans. It is the result of an abnormality in the amount, structure, or function of von Willebrand factor (vWF), a glycoprotein important in maintaining normal hemostasis.. In children with vWD, the most frequent presentation is easy bruising and epistaxis.
Nina A. Guzzetta, Laura A. Downey
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