Results 41 to 50 of about 75,319 (256)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Experimental Tests and Aeroacoustic Simulations of the Control of Cavity Tone by Plasma Actuators
Applied Sciences, 2017 A plasma actuator comprising a dielectric layer sandwiched between upper and lower electrodes can induce a flow from the upper to lower electrode by means of an externally-applied electric field.
Hiroshi Yokoyama +2 more
doaj +1 more source
Российский технологический журнал, 2022 Objectives. The study aimed to examine vortex structures formed during the interaction of incident and reflected shock waves in a cylindrical channel.
I. G. Lebo, I. V. Obruchev
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
New Journal of PhysicsWe derive the most general expression for the Skyrmion topological charge for a two-dimensional spin texture, valid for any type of boundary conditions or for any arbitrary spatial region within the texture.
S Sánchez-Reséndiz +3 more
doaj +1 more source
Fidimag – A Finite Difference Atomistic and Micromagnetic Simulation Package
Journal of Open Research Software, 2018 Fidimag is an open-source scientific code for the study of magnetic materials at the nano- or micro-scale using either atomistic or finite difference micromagnetic simulations, which are based on solving the Landau-Lifshitz-Gilbert equation. In addition,
Marc-Antonio Bisotti +6 more
doaj +1 more source
Superheating field in superconductors with nanostructured surfaces
Frontiers in Electronic Materials, 2023 We report calculations of a DC superheating field Hsh in superconductors with nanostructured surfaces. Numerical simulations of the Ginzburg–Landau (GL) equations were performed for a superconductor with an inhomogeneous impurity concentration, a thin ...
W. P. M. R. Pathirana, A. Gurevich
doaj +1 more source
Surf-zone vortices over stepped topography [PDF]
, 2004 The problem of vortical motions in the surf zone is simplified by taking the bottom topography to be piecewise flat while allowing finite-height jumps in depth between flat regions.
Johnson, ER, McDonald, NR
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source