Results 51 to 60 of about 57,568 (319)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatial distribution of rolled up Kelvin-Helmholtz vortices at Earth's dayside and flank magnetopause [PDF]

, 2012
The Kelvin-Helmholtz Instability (KHI) can drive waves at the magnetopause. These waves can grow to form rolled-up vortices and facilitate transfer of plasma into the magnetosphere.
C. P. Escoubet, Pu ZY, Borg, A. L., Soucek, J., Y. V. Bogdanova, Bogdanova YV, J. P. Eastwood, Sibeck DG, Shen C, Wang, J., Panov EV, Wang J, M. G. G. T. Taylor, Borg AL, Fazakerley, A. N., J. Berchem, Bogdanova, Y. V., Shen, C., M. W. Dunlop, Lavraud, B., Dunlop, M. W., Phan, T., A. L. Borg, Volwerk, M., H. Laakso, Berchem, J., Wild JA, J. K. Shi, Constantinescu OD, Eastwood JP, J. A. Wild, A. N. Fazakerley, Laakso H, T. Phan, C. Shen, Lavraud B, Taylor, M. G. G. T., Frey, H. U., Sibeck, D. G., Z. Y. Pu, Berchem J, Taylor MGGT, Shi JK, Laakso, H., H. U. Frey, Hasegawa, H., Soucek J, Panov, E. V., Pu, Z. Y., E. V. Panov, Frey HU, Masson, A., Hasegawa H, Phan T, J. Soucek, D. G. Sibeck, Escoubet CP, Dunlop MW, J. Wang, M. Volwerk, Masson A, H. Hasegawa, A. Masson, Wild, J. A., Constantinescu, O. D., O. D. Constantinescu, Volwerk M, Eastwood, J. P., Shi, J. K., Escoubet, C. P., Fazakerley AN, B. Lavraud   +71 more
core   +1 more source

Reducing the extent of vortices upstream of the sliding valve [PDF]

Journal of Hydraulic Structures
The purpose of this research is to provide a solution to eliminate the vortices formed upstream of the sliding valve. The effect of the threshold with the geometric shapes of semi-cylinder, cylinder, pyramid and rectangular cube in different widths of 5,
Parisa Ebadzadeh, Hamidreza Abbaszadeh, Rasoul Daneshfaraz, Reza Norouzi   +3 more
doaj   +1 more source

From Mixing to the Large Scale Circulation: How the Inverse Cascade Is Involved in the Formation of the Subsurface Currents in the Gulf of Guinea

Fluids, 2020
In this paper, we analyse the results from a numerical model at high resolution. We focus on the formation and maintenance of subsurface equatorial currents in the Gulf of Guinea and we base our analysis on the evolution of potential vorticity (PV).
Fernand Assene, Yves Morel, Audrey Delpech, Micael Aguedjou, Julien Jouanno, Sophie Cravatte, Frédéric Marin, Claire Ménesguen, Alexis Chaigneau, Isabelle Dadou, Gael Alory, Ryan Holmes, Bernard Bourlès, Ariane Koch-Larrouy   +13 more
doaj   +1 more source

Effects of Blade Number on the Propulsion and Vortical Structures of Pre-Swirl Stator Pump-Jet Propulsors

Journal of Marine Science and Engineering, 2021
Reducing the noise of the underwater propulsor is gaining more and more attention in the marine industry. The pump-jet propulsor (PJP) is an extraordinary innovation in marine propulsion applications.
Han Li, Qiaogao Huang, Guang Pan, Xinguo Dong, Fuzheng Li   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Quasi-geostrophic shallow-water doubly-connected vortex equilibria and their stability [PDF]

, 2013
H.P. acknowledges the support of a NERC studentship. D.G.D. received support for this research from the UK Engineering and Physical Sciences Research Council (grant EP/H001794/1).We examine the form, properties, stability and evolution of doubly ...
Dritschel, David Gerard, Plotka, Hanna
core   +1 more source

Hyperviscous vortices

Journal of Fluid Mechanics, 1994
The structure of diffusing planar and axisymmetric vortices of the hyperviscous Navier-Stokes equations is studied for different orders of the dissipative operator. It is found that, except for the classical Newtonian case, the vorticity decays at large distances by means of oscillatory tails, containing circulation of alternating signs.
openaire   +3 more sources

Hodographic vortices [PDF]

Physics Letters A, 2009
Vortices are screw phase dislocations associated with helicoidal wave-fronts. In nonlinear optics, vortices arise as singular solutions to the phase-intensity equations of geometric optics. They exist for a general class of nonlinear response functions. In this sense, vortices possess a universal character. Analysis of geometric optics equations on the
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source