Results 131 to 140 of about 34,477 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Vouching for Vouchers

open access: yes, 2019
The article discusses the concept of using book vouchers in buying a book. Topics covered include the use of book vouchers at the Portland Book Festival (PBF) held each November, advantages of using vouchers, and possible correlation between increased ...
Berens, Kathi Inman
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Regulation in the Market for Education and Optimal Choice of Curriculum [PDF]

open access: yes
We analyze educational institutions’ incentives to set up demanding or lax curricula in duopolistic markets for education with endogenous enrolment of students.
Ansgar Wohlschlegel, Gerald Eisenkopf
core  

K-12 Voucher Programs and Education Policy

open access: yesEducation Policy Analysis Archives, 2002
Since the 1983 report, A Nation at Risk, the performance of public schools has been increasingly scrutinized, and a variety of reforms designed to increase student achievement enacted. Among the reforms discussed, much attention has focused on increasing
Dan Laitsch
doaj  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

The Effects of Housing Assistance on Labor Supply: Evidence from a Voucher Lottery [PDF]

open access: yes
This study estimates the effects of means-tested housing programs on labor supply using data from a randomized housing voucher wait-list lottery in Chicago.
Jens Ludwig, Brian A. Jacob
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Innovative voucher as a prospect tool for grant funding

open access: yesEkonomika Nauki, 2015
The article aims to explore innovative international practice for advancing the mechanisms of distributing grant funding. Authors analyze a practical case study of successful implementation of innovative vouchers overseas, and draw parallels with regard ...
V. A. Barinova, V. A. Eremkin
doaj  

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