Results 131 to 140 of about 160,309 (307)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A Study of the Unexplored Aspect of Energy Poverty: Overheating Risk Analysis

open access: yesSAGE Open
Energy poverty, defined as the inability of households to afford adequate heating or cooling, is worsened by anthropogenic climate change, leading to increased energy demand and indoor comfort challenges. This study addresses a gap in summer fuel poverty
Younhee Choi   +3 more
doaj   +1 more source

Impact of Voucher Design on Public School Performance: Evidence from Florida and Milwaukee Voucher Programs [PDF]

open access: yes
This paper examines the impact of vouchers in general, and voucher design in particular, on public school performance. It argues that all voucher programs are not created equal.
Rajashri Chakrabarti
core  

Insulting offer of adidas food vouchers rejected by workers [PDF]

open access: yes, 2012
This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
Clean Clothes Campaign
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Vouchers, Public School Response and the Role of Incentives: Evidence from Florida [PDF]

open access: yes
In this paper, I analyze the behavior of public schools facing vouchers. The literature on the effect of voucher programs on public schools typically focuses on student and mean school scores.
Rajashri Chakrabarti
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Driving to Opportunity: Understanding the Links among Transportation Access, Residential Outcomes, and Economic Opportunity for Housing Voucher Recipients [PDF]

open access: yes, 2014
In the 1990s and early 2000s, the Department of Housing and Urban Development sponsored two major experiments to test whether housing choice vouchers propelled low-income households into greater economic security, the Moving to Opportunity for Fair ...
Arthur Taz George   +3 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Unemployment vouchers versus low-wage subsidies [PDF]

open access: yes, 2002
The paper examines the relative effectiveness of two policy proposals in reducing unemployment and working poverty: unemployment vouchers and low-wage subsidies.
Orszag, Jonathan Michael   +1 more
core  

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