Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
The Views of Swim School Providers on Impacts of a Population-Level Swimming Lesson Voucher Program. [PDF]
Peden AE, Mead E, Macniven R.
europepmc +1 more source
Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim +3 more
wiley +1 more source
The Transition from Welfare to Work [PDF]
We consider the effects the child care market, child care vouchers, early childhood education programs, and welfare reforms have on welfare recipients in their transition from welfare to work.
Ann Dryden Witte +2 more
core
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Evaluating the Economic Impact of Learn-to-Swim Programmes: A Cost-Benefit Analysis of the First Lap Voucher Programme in Australia. [PDF]
Wang S, Macniven R, Peden A, Angell B.
europepmc +1 more source
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
Priority without progress: the FDA's neglected tropical disease voucher program after 18 years. [PDF]
Goh M, Outterson K, Kesselheim AS.
europepmc +1 more source
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman +9 more
wiley +1 more source
The Veggie Vouchers intervention to promote SNAP fruit and vegetable incentive program use for families with food insecurity: a single arm feasibility study. [PDF]
Adams EL +11 more
europepmc +1 more source

