Results 1 to 10 of about 7,193 (199)

Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein [PDF]

Molecular Medicine
Vacuolar protein sorting-associated protein 35 (VPS35), a pivotal constituent of the retromer complex, mediates the retrograde trafficking of endosomal cargoes in the cytoplasm.
Luping Zhang, Yonghong Nie, Tuo Tang, Yanji Lu, Wenlong Li, Xian Hong, Qiang Li, Aixue Zheng, Yongpei Li, Jianwen Zhou, Li Fan, Tao Wang, Zhihui Deng   +12 more
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Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy. [PDF]

PLoS ONE, 2017
Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson's disease (PD) and Alzheimer ...
Wei Liu, Fu-Lei Tang, Sen Lin, Kai Zhao, Lin Mei, Jian Ye, Wen-Cheng Xiong   +6 more
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VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model [PDF]

Frontiers in Aging Neuroscience
BackgroudVPS35, a core component of the retromer complex, has been closely associated with neurodegenerative disorders, particularly Parkinson’s disease (PD). The VPS35 D620N mutation has been identified as a pathogenic variant in familial PD.
Mei Jiang, Mei Jiang, Xu Deng, Xu Deng, Zijie Qiu, Zijie Qiu, Yuan Fu, Yuan Fu, Zixiong Qiu, Zixiong Qiu, Jiankai Zhang, Jiankai Zhang, Hongxia Fu, Hongxia Fu, Jie Li, Jie Li, Yao Luo, Yao Luo, Xiaojun Cui, Xiaojun Cui   +19 more
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TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia. [PDF]

PLoS Biology
TAR DNA-binding protein 43 (TDP-43) dysfunction is a hallmark of several neurodegenerative diseases, including frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer's disease.
Vidhya Maheswari Jawahar, Yi Zeng, Ellen M Armour, Mei Yue, Kathryn Citrano, Anastasiia Lovchykova, Madison M Reeves, Bailey Rawlinson, Michael DeTure, Judith A Dunmore, Yuping Song, Sophie K Ball, Zbigniew K Wszolek, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Gregory S Day, Scott A Small, Dennis W Dickson, Michael E Ward, Tania F Gendron, Yongjie Zhang, Mercedes Prudencio, Aaron D Gitler, Leonard Petrucelli   +24 more
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Exploring the role of mitochondrial dysfunction-related genes in osteoporosis using weighted gene co-expression network analysis and machine learning [PDF]

European Journal of Medical Research
Background Osteoporosis (OP) is a prevalent age-related disease characterized by bone loss and increased fracture risk. Mitochondrial dysfunction is tightly associated with OP pathogenesis.
Han-bing Zeng, Xiang-tao Yuan, Lian-guo Wu, Rui-kun Zhang, Kun Yan, Xiao-bo Lai, Peng Xu, Xin-miao Yao   +7 more
doaj   +2 more sources

Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition [PDF]

npj Parkinson's Disease
The D620N variant in Vacuolar Protein Sorting 35 (VPS35) causes autosomal-dominant, late-onset Parkinson’s disease. VPS35 is a core subunit of the retromer complex that canonically recycles transmembrane cargo from sorting endosomes.
A. Kamesh, C. A. Kadgien, N. Kuhlmann, S. Coady, A. Pietrantonio, Y. Cousineau, A. Khayachi, A. Jurado Santos, E. P. Hurley, J. C. Barron, M. P. Parsons, A. J. Milnerwood   +11 more
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Hsp90 Inhibitor STA9090 induced VPS35 related extracellular vesicle release and metastasis in hepatocellular carcinoma

Translational Oncology, 2022
Heat shock protein 90 (Hsp90) has been an important therapeutic target for cancer therapy for decades. Unexpectedly, the monotherapy of N-terminal Hsp90 inhibitor STA9090 related clinical trials halted in phase III, and metastases were reported in animal
Wenchong Tan, Jinxin Zhang, Lixia Liu, Manfeng Liang, Jieyou Li, Zihao Deng, Zhenming Zheng, Yaotang Deng, Chenyang Liu, Yan Li, Guantai Xie, Jiajie Zhang, Fei Zou, Xuemei Chen   +13 more
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Critical Role of Neuronal Vps35 in Blood Vessel Branching and Maturation in Developing Mouse Brain

Biomedicines, 2022
Vps35 (vacuolar protein sorting 35), a key component of retromer, plays a crucial role in selective retrieval of transmembrane proteins from endosomes to trans-Golgi networks.
Yang Zhao, Daehoon Lee, Xiao-Juan Zhu, Wen-Cheng Xiong   +3 more
doaj   +1 more source

A novel autophagy-related genes prognostic risk model and validation of autophagy-related oncogene VPS35 in breast cancer

Cancer Cell International, 2021
Background Accumulating evidence implies that autophagy plays a critical role in breast cancer development and progression. It is crucial to screen out autophagy-related encoding genes (ARGs) with prognostic value in breast cancer and reveal their ...
Xiaoying Li, Yu Cao, Xinmiao Yu, Feng Jin, Yang Li   +4 more
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VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancerResearch in context

EBioMedicine, 2023
Summary: Background: Vacuolar protein sorting-associated protein 35 (VPS35) is a core component of the retromer complex which mediates intracellular protein transport. It is well known that dysfunctional VPS35 functions in the accumulation of pathogenic
Junxian Yu, Haoran Feng, Qingqing Sang, Fangyuan Li, Mengdi Chen, Beiqin Yu, Zhuoqing Xu, Tao Pan, Xiongyan Wu, Junyi Hou, Zhenggang Zhu, Chao Yan, Liping Su, Jianfang Li, Bingya Liu   +14 more
doaj   +1 more source