Results 91 to 100 of about 7,193 (199)

Distinction and mutual Influences between Parkinson's Disease‐related and unrelated Chronic Pain

Movement Disorders Clinical Practice, Volume 13, Issue 2, Page 464-474, February 2026.
Abstract Background Chronic pain (i.e. > 3 months) is a common nonmotor symptom in patients with Parkinson's disease (PD), but the attribution to PD is critical for further treatment. Objectives We explored the PD Pain Classification System (PD‐PCS) criteria for the diagnosis of PD‐related pain and mutual influences between PD‐related and PD‐unrelated ...
Jonathan Hunger, Florian Brugger, Georg Kägi, Jens Carsten Möller, Nathalie Hollenstein, David H. Benninger, Michele Tinazzi, Julien F. Bally, Roman Gonzenbach, Daniel Ciampi de Andrade, Santiago Perez Lloret, Veit Mylius   +11 more
wiley   +1 more source

Parkinson's disease in Sub-Saharan Africa: A review of epidemiology, genetics and access to care [PDF]

, 2018
A low prevalence of Parkinson's disease (PD) has been reported in the Sub-Saharan Africa (SSA) region. The genetic causes and clinical features of PD in this region have been poorly described. Very few reports have examined the availability and access to
Akinyemi, Balogou, Lombard, Ogunniyi, Walker, Walker   +5 more
core   +2 more sources

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

eLife, 2020
Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult ...
Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman   +10 more
doaj   +1 more source

Multifaceted Roles of Retromer in EGFR Trafficking and Signaling Activation

Cells, 2022
Mammalian retromer complex contributes to multiple early endosome-associated trafficking pathways whose origins are dependent on which sorting nexin (SNX) they are complexed with.
Zhe Yang, Zhengyang Feng, Zebin Li, Rohan D. Teasdale   +3 more
doaj   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice [PDF]

Human Molecular Genetics, 2016
Point mutations in the vacuolar protein sorting 35 gene (VPS35) have been associated with an autosomal dominant form of late-onset Parkinson disease (PARK17), but there has been considerable debate over whether it is caused by a loss- or gain-of-function mechanism and over the intracellular target site of neurotoxicity.
Nobutaka, Ishizu, Daishi, Yui, Akira, Hebisawa, Hidenori, Aizawa, Wanpeng, Cui, Yuko, Fujita, Kenji, Hashimoto, Itsuki, Ajioka, Hidehiro, Mizusawa, Takanori, Yokota, Kei, Watase   +10 more
openaire   +2 more sources

Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response

EBioMedicine, 2016
Parathyroid hormone (PTH) plays critical, but distinct, roles in bone remodeling, including bone formation (anabolic response) and resorption (catabolic response).
Lei Xiong, Wen-Fang Xia, Fu-Lei Tang, Jin-Xiu Pan, Lin Mei, Wen-Cheng Xiong   +5 more
doaj   +1 more source

Levodopa‐Carbidopa Intestinal Gel Improves Dyskinesia in Parkinson's Disease: Post Hoc Analysis from the COSMOS Study

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 98-107, January 2026.
Abstract Background Dyskinesia is a debilitating complication of dopaminergic therapy in advanced Parkinson's disease. Objectives To evaluate the effect of levodopa‐carbidopa intestinal gel (LCIG) on dyskinesia burden. Methods This is a post hoc analysis of the retrospective, observational COmedication Study assessing Mono‐ and cOmbination therapy with
Alfonso Fasano, Cleanthe Spanaki, Tanya Gurevich, Robert Jech, Per Svenningsson, József Szász, Lydia Vela‐Desojo, Mihaela Simu, Lars Bergmann, Abdallah Saad, Juan Carlos Parra, Norbert Kovács   +11 more
wiley   +1 more source

Subcutaneous Apomorphine Infusion Initiation Is Associated with Impulse Control Disorder Attenuation in Advanced Parkinson's Disease Patients: Insights from the French NS‐Park Cohort

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 142-153, January 2026.
Abstract Background Impulse control disorders (ICD) are common non‐motor complications in Parkinson's disease (PD), particularly in patients receiving oral dopamine agonists (DA). Continuous subcutaneous apomorphine infusion (CSAI) is a device‐aided therapy for advanced PD, but its effects on ICD remain underexplored in real‐world settings.
Clément Desjardins, Paulo André Dias Bastos, Aymeric Lanore, Christine Brefel‐Courbon, Isabelle Benatru, Caroline Giordana, Anne Doe de Maindreville, Giovanni Castelnovo, Philippe Remy, Luc Defebvre, Claire Thiriez, Stéphane Prange, Jean‐Luc Houeto, Alexandra Samier Foubert, Fabienne Ory‐Magne, Raquel Pinhero Barbosa, Nathalie Bertille, Jean‐Christophe Corvol, Olivier Rascol, Margherita Fabbri, on behalf of the NS‐Part Cohort study group, Jean‐Christophe Corvol, Olivier Rascol, Margherita Fabbri, Wassilios Meissner, Stéphane Thobois, Luc Defebvre, Helene Esperou, Florence Tubach, Yann De Rycke, Layidé Roufai, Dalila Ouazib, Sandra Zarrad, Fatma Khelifi, Florence Tubach, Yann De Rycke, Nathalie Bertille, Vanessa Rousseau, Samuel Tessier, Margherita Fabbri, David Tavel, Dounya Metdaoui, Avigaelle Abitbol, Mathias Antunes, Alexis Brice, Suzanne Lesage, Christelle Tessson, Fanny Casse, Mélanie Ferrien, Guillaume Cogan, Lisa Welment, Thierry Moulin, Wassilios Meissner, Claire Thiriez, Stéphane Thobois, Christian Geny, Solène Frismand, Anne‐Gaëlle Corbille, Caroline Giordana, Giovanni Castelnovo, Isabelle Benatru, Sophie Drapier, David Maltete, Christine Tranchant, Olivier Rascol, Mickael Aubignat, Marie Mongin, Matthieu Bereau, Alexandra Foubert‐Samier, Brice Laurens, Sylvain Vergnet, Thomas Boraud, David Bendetowicz, Jade Sarrabere, Dominique Guehl, Pierre Burbaud, Paul‐Alexandre Pfeiffer, Gilles Defer, Bérengère Debilly, Philippe Derost, Alice Dormeuil, Aimée Petit, Alban Gravier, Vincent Schneider, Lucie Garnier, Nicolas Carriere, Olivier Colin, Philippe Couratier, Chloé Laurencin, Stephane Prange, Paul Jaulent, Bruno Plus, Helene Gervais‐Bernard, Alexandre Eusebio, Frédérique Fluchere, Stephan Grimaldi, Valentin Mira, Tatiana Witjas, Mahmoud Charif, Ophelie Forster, Alix Durand, Pauline Prin, Lucie Hopes, Amory Jardel, Salome Puisieux, Guillemette Clement, Philippe Damier, Tiphaine Rouaud, Pascal Derkinderen, Arthur Lionnet, Adrien De Guilhem De Lataillade, Cosmin Alecu, Charlotte Heraud, Marie De Verdal, Graziella Mangone, Sara Sambin, Aymeric Lanore, Thomas Courtin, Louise‐Laure Mariani, Fouad Khoury, Poornima Menon, Florence Cormier‐Dequaire, Emmanuel Flamand‐Roze, David Grabli, Elodie Hainque, Marie Vidhaillet, Aurélie Meneret, Cécile Delorme, Cendrine Foucard, Florian Von Raison, Alexis Elbaz, Andreas Hartmann, Vincent Leclercq, Theodore Soulier, Daniel Torres, Giulia Coarelli, Giorgia Querin, Fabien Hauw, Margaux Dunoyer, Solène Ansquer, Frederique Leh, Marion Leclercq, Simon Lamy, Guillaume Carey, Guillaume Costentin, Clemence Hardy, Mathieu Anheim, Ouhaid Lagha Boukbiza, Thomas Wirth, Jimmy Voirin, Marie Des Neiges Santin, Thomas Bogdan, Margherita Fabbri, Christine Brefel Courbon Ory‐Magne, Clemence Leung, Hélène Catala, Gabrielle Sill, Raquel Pinheiro Barbosa, Lucy Famer, Lucie Braccagni, Hiba Sifaoui, Juliette Palisson, Kenza Benrahmoune Idrissi, Astrid Causel, Lydie Romeo, Constance Bissessur, Audace Cure‐Martin, Charline Compagne, Sandrine Dupouy, Sandrine Villars, Wei‐Ho Lai, Rachida Bari, Damien Chevanne, Elodie Durand, Isabelle Rieu, Stephane Bernard, Corinne Garsault, Nathalie Meunier, Alexia Cresson, Marine Sgard, Marie Dreano, Justine Montillot, Renaud Massart, Pascale Grebent, Pierre Pelissier, Valérie Santraine, Thomas Gaudin, Pierre Boutet, Cécile Thuilier, Coralie Chalot, Céline Prevost, Hélène Videaud, Justine Picut, Christian Tarrade, Catherine Caire, Hélène Merle, Elise Metereau, Mathilde Millot, Chloe Bernardi, Emilie Favre, Adelaide Jaulent, Laura Mundler, Blandine Dufresne, Eve Benchetrit, Valérie Driss, Alexia Arifi, Maura Rodrigues, Lili Le Monnier, Nathalie Dumont, Virginie Bablon, Régis Frenais, Caroline Herve, Christelle Guimber, Vanessa Ferrier, Elodie David, Christina Faroul, Leslie Fra, Elsa Foucaran, Fatima‐Ezzahra Ennaji, Jeremy Bonetto, Ryad Ladghem‐Chikouche, Le Mickael, Sophie Liot, Sonia Messar, Hamza Salah, Amelie Bernardo, Naoual Serari, Emilie Rabois, Carole David, Zoe Fournier, Margaux Bonnaire‐Verdier, Elise Chevaillier, Françoise Kestens, Rozenn Gourhan, Sandra Lopez‐Alfaro, Jean‐François Houvenaghel, Mélanie Alexandre, Christine Bourdonnais, Linda Vernon, Ahmed Boumediene, Hugo Rummel, Céline Julie, Nadine Longato, Célie Phillipps, Anne Claire Andries‐Ros, Stéphanie Bras, Estelle Harroch, Claudia Gillet, Yoan Herades, Eva Camgrand   +249 more
wiley   +1 more source

Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 198-207, January 2026.
Abstract Background Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The basal forebrain (BF), a key cholinergic structure, is a site of known pathology in later stages of Lewy body disorders.
Lachlan Churchill, Ajay Konuri, Anna Ignatavicius, Jack Anderson, Simon J.G. Lewis, Elie Matar   +5 more
wiley   +1 more source