Results 111 to 120 of about 7,193 (199)

Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017
Defect in the complex I of the mitochondrial electron-transport chain is a characteristic of Parkinson's disease (PD) which is thought to play a critical role in the disease pathogenesis. Mutations in vacuolar protein sorting 35 (VPS35) cause autosomal dominant PD and we recently demonstrated that pathogenic VPS35 mutations cause mitochondrial damage ...
Leping Zhou, Wenzhang Wang, Charles Hoppel, Jun Liu, Xiongwei Zhu   +4 more
openaire   +2 more sources

A Systematic Review of the Parkinson's Foundation Hospital Care Recommendations

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 29-43, January 2026.
Abstract Background People with Parkinson's disease (PwP) face increased risks of complications and longer hospital stays compared to the general population. Four major factors contribute to increased morbidity and mortality during hospitalization: medication timing errors, administration of harmful medications, restricted mobility, and dysphagia ...
Ariane Veilleux Carpentier, Irene A. Malaty, Peter A. LeWitt, Hooman Azmi, Anne Brooks, Edward Pollak, Ellen L. Air, Heather Simpson, Jaime Thomas, Florian P. Thomas, Lisa Cocoziello, Sheera Rosenfeld, Michael S. Okun   +12 more
wiley   +1 more source

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

Neurobiology of Disease, 2012
The retromer complex plays an important role in intracellular transport, is highly expressed in the hippocampus, and has been implicated in the trafficking of the amyloid precursor protein (APP).
Akhil Bhalla, Christopher P. Vetanovetz, Etienne Morel, Zeina Chamoun, Gilbert Di Paolo, Scott A. Small   +5 more
doaj   +1 more source

Enhancing the utility of Proteomics Signature Profiling (PSP) with Pathway Derived Subnets (PDSs), performance analysis and specialised ontologies [PDF]

, 2013
10.1186/1471-2164-14-35BMC ...
Fan, M., Goh, W.W.B., Low, H.S., Sergot, M., Wong, L.   +4 more
core   +2 more sources

Efficacy and Safety of IncobotulinumtoxinA for Treatment of Sialorrhea: A Multicenter, Phase 3 Study in Japan

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 120-130, January 2026.
This study demonstrated significant treatment efficacy and safety of incobotulinumtoxinA injection in Japanese patients with chronic sialorrhea caused by Parkinson's disease and other neurological conditions. Suppression of salivary secretion and improvement in drooling symptoms were also observed throughout 48 weeks.
Nobutaka Hattori, Yohei Mukai, Noriko Nishikawa, Kazuko Hasegawa, Masahiko Tomiyama, Yasuyoshi Kimura, Yoshio Tsuboi, Ryosuke Takahashi, Ryota Nakamura, Yuishin Izumi, Hirohisa Watanabe, Morinobu Seki, Kenji Sekiguchi, Shohei Tateishi, Yusaku Matsushita, Yusaku Nakamura   +15 more
wiley   +1 more source

Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration

Nature Communications
Vacuolar protein sorting 35 (VPS35), the core component of the retromer complex which regulates endosomal trafficking, is genetically linked with Parkinson’s disease (PD). Impaired vision is a common non-motor manifestation of PD.
Cheng Fu, Nan Yang, Jen-Zen Chuang, Nobuyuki Nakajima, Satoshi Iraha, Neeta Roy, Zhenquan Wu, Zhichun Jiang, Wataru Otsu, Roxana A. Radu, Howard Hua Yang, Maxwell Ping Lee, Tilla S. Worgall, Wen-Cheng Xiong, Ching-Hwa Sung   +14 more
doaj   +1 more source

The Genetic Basis of Cognitive Impairment and Dementia in Parkinson's Disease. [PDF]

, 2016
Cognitive dysfunction is a common feature of Parkinson's disease (PD) with mild cognitive impairment affecting around a quarter of patients in the early stages of their disease, and approximately half developing dementia by 10 years from diagnosis ...
Collins, Lucy M, Williams-Gray, Caroline H   +1 more
core   +2 more sources

Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau

Journal of Inflammation Research, 2021
Alessia Filippone, Tiffany Smith, Domenico Pratico Alzheimer’s Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USACorrespondence: Domenico PraticoAlzheimer’s Center at Temple, Lewis Katz School of Medicine ...
Filippone A, Smith T, Pratico D
doaj  

Neuronal Proteomic Analysis Of The Ubiquitinated Substrates Of The Disease-Linked E3 Ligases Parkin And Ube3a [PDF]

, 2018
Both Parkin and UBE3A are E3 ubiquitin ligases whose mutations result in severe brain dysfunction. Several of their substrates have been identified using cell culture models in combination with proteasome inhibitors, but not in more physiological ...
Arizmendi Bastarrika, Jesús María, Martínez, Aitor, Mayor Martínez, Ugo, Osinalde Moraleja, Nerea, Ramírez Sánchez, Juan Manuel   +4 more
core   +5 more sources

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5 [PDF]

, 2017
Legionella pneumophila can cause Legionnaires’ disease and replicates intracellularly in a distinct Legionella-containing vacuole (LCV). LCV formation is a complex process that involves a plethora of type IV-secreted effector proteins.
Bärlocher, K, Hilbi, H, Hohl, M, Hutter, CAJ, Letourneur, F, Seeger, MA, Steiner, B, Swart, AL, Welin, A   +8 more
core   +4 more sources