Results 11 to 20 of about 7,193 (199)
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration [PDF]
Human Molecular Genetics, 2014 Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD).
A. Fiser +38 more
core +11 more sources
VPS35, the Retromer Complex and Parkinson’s Disease [PDF]
Journal of Parkinson’s Disease, 2017 Mutations in the vacuolar protein sorting 35 ortholog ( VPS35 ) gene encoding a core component of the retromer complex, have recently emerged as a new cause of late-onset, autosomal dominant familial Parkinson’s disease (PD).
Erin T. Williams +2 more
doaj +3 more sources
VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiology
Neurobiology of Disease, 2020 Mutations in VPS35 (PARK17), a key molecule in the retromer complex, are a rare cause of autosomal dominant Parkinson's disease (PD), the second most common neurodegenerative disorder. VPS35 exerts crucial functions within the cell in terms of regulating
Gianni Cutillo +2 more
doaj +3 more sources
VPS35-Based Approach: A Potential Innovative Treatment in Parkinson's Disease [PDF]
Frontiers in Neurology, 2019 Several symptomatic treatments for Parkinson's disease (PD) are currently available. Still, the challenge today is to find a therapy that might reduce degeneration and slow down disease progression.
Simona Eleuteri +2 more
doaj +4 more sources
VPS35: A new player in Parkinson's Disease [PDF]
Movement Disorders, 2011 The identification of genetic mutations that cause Parkinson's disease (PD) in rare families has been the bedrock of investigation into the molecular pathogenesis of PD. These mutations are used to understand and model disease, in a process aimed at finding viable points of therapeutic intervention that are based on etiology, rather than being based on
Zoé Hanss +9 more
+10 more sources
VPS35 Mutations in Parkinson Disease [PDF]
The American Journal of Human Genetics, 2011 The identification of genetic causes for Mendelian disorders has been based on the collection of multi-incident families, linkage analysis, and sequencing of genes in candidate intervals. This study describes the application of next-generation sequencing technologies to a Swiss kindred presenting with autosomal-dominant, late-onset Parkinson disease ...
Vilariño-Güell, Carles +32 more
openaire +5 more sources
Genes and Diseases, 2021 Vesicle Protein Sorting 35 (VPS35) is a novel oncogene that promotes tumor growth through the PI3K/AKT signaling in hepatocellular carcinoma (HCC). However, the role of VPS35 in HCC metastasis and the underlying mechanisms remain largely unclear. In this
Yi Liu +7 more
doaj +1 more source
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology [PDF]
The Journal of Experimental Medicine, 2011 VPS35, a major component of the retromer complex, is important for endosome-to-Golgi retrieval of membrane proteins. Although implicated in Alzheimer’s disease (AD), how VPS35 regulates AD-associated pathology is unknown. In this paper, we show that hemizygous deletion of Vps35 in the Tg2576 mouse model of AD led to earlier-onset AD-like phenotypes ...
Wen, Lei +15 more
openaire +3 more sources
npj Parkinson's Disease, 2023 Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and learning behaviors, and can be observed during the prodromal phase of Parkinson’s disease (PD).
Mengfei Bu +11 more
doaj +1 more source
Cell & Bioscience, 2021 Objective Dysregulation of KLF7 participates in the development of various cancers, but it is unclear whether there is a link between HCC and aberrant expression of KLF7.
Yarong Guo +7 more
doaj +1 more source