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VPS35 Downregulation Alters Degradation Pathways in Neuronal Cells
Journal of Alzheimer's Disease, 2021Background: The vacuolar protein sorting 35 (VPS35) is the main component of the retromer recognition core complex system which regulates intracellular cargo protein sorting and trafficking. Downregulation of VPS35 has been linked to the pathogenesis of neurodegenerative disorders such Alzheimer’s and Parkinson’s diseases via endosome dysregulation ...
Filippone A., Li J. -G., Pratico D.
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Mechanisms of VPS35-mediated neurodegeneration in Parkinson's disease
2021Parkinson's disease is a sporadic and common neurodegenerative movement disorder resulting from the complex interplay between genetic risk, aging and environmental exposure. Familial forms of PD account for ~10% of cases and are known to result from the inheritance of mutations in at least 15 genes. Mutations in the vacuolar protein sorting 35 ortholog
Dorian, Sargent, Darren J, Moore
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The VPS35 gene and Parkinson's disease
Movement Disorders, 2013ABSTRACTParkinson's disease (PD), the second most common age‐related neurodegenerative disease, is characterized by loss of dopaminergic and nondopaminergic neurons, leading to a variety of motor and nonmotor symptoms. In addition to environmental factors, genetic predisposition and specific gene mutations have been shown to play an important role in ...
Hao, Deng, Kai, Gao, Joseph, Jankovic
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Vps35‐dependent recycling of Trem2 regulates microglial function
Traffic, 2016Triggering receptor expressed on myeloid cells 2 (Trem2), an immune‐modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia.
Jie, Yin +5 more
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1994
Abstract ““ “ p - _- Cells carrying a null allele of VPS35 exhibit a differential vacuolar protein sorting defect. The sorting of CPY is drastically affected in !wps35 mutant cells; >95% of CPY is secreted in its Golgi modified p2 precursor form.
B Horazdovsky, G Par,ivicini,, S D Enu
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Abstract ““ “ p - _- Cells carrying a null allele of VPS35 exhibit a differential vacuolar protein sorting defect. The sorting of CPY is drastically affected in !wps35 mutant cells; >95% of CPY is secreted in its Golgi modified p2 precursor form.
B Horazdovsky, G Par,ivicini,, S D Enu
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VPS35 Parkinson’s disease phenotype resembles the sporadic disease
Journal of Neural Transmission, 2014Recently a new autosomal dominant Parkinson's disease mutation (p.Asp620Asn) in the VPS35 gene was discovered. The clinical features of 14 PD patients with this mutation from three Austrian families were evaluated. Age at disease-onset appears lower and depression was more common in Austrian patients compared to sporadic PD patients.
Walter, Struhal +7 more
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The Role of VPS35 in the Pathobiology of Parkinson’s Disease
Cellular and Molecular Neurobiology, 2020The vacuolar protein sorting 35 (VPS35) gene located on chromosome 16 has recently emerged as a cause of late-onset familial Parkinson's disease (PD) (PARK17). The gene encodes a 796-residue protein nearly ubiquitously expressed in human tissues. The protein localizes on endosomes where it assembles with other peripheral membrane proteins to form the ...
Jenny Sassone +5 more
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Exploring the triad:
Abstract Vacuolar protein sorting 35 (VPS35), a critical component of the retromer complex, plays a pivotal role in the pathogenesis of neurodegenerative diseases (NDs). It is involved in protein transmembrane sorting, facilitating the transport from endosomes to the trans‐Golgi network (TGN) and plasma membrane ...
Zixiong Qiu +4 more
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Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking
Biochemical and Biophysical Research Communications, 2010The retromer complex, which mediates retrograde transport from endosomes to the trans-Golgi network, is a heteropentameric complex that contains a multifunctional cargo recognition heterotrimer consisted of the vacuolar protein sorting (Vps) subunits Vps26, Vps29, and Vps35. In mammals, there are two different isoforms of Vps26, Vps26a and Vps26b, that
Ekyune, Kim +11 more
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