Results 21 to 30 of about 7,193 (199)

VPS35 Parkinson mutation impairs autophagy via WASH [PDF]

Cell Cycle, 2014
Parkinson disease (PD) is a progressive neurodegenerative disorder affecting approximately 1% of the population over age 65. It is characterized by loss of dopaminergic neurons in the substantia nigra along with protein aggregates known as Lewy bodies in surviving neurons. The disease leads to debilitating motor symptoms, as well as some nonmotor signs.
Zavodszky, Eszter, Seaman, Matthew NJ, Rubinsztein, David C   +2 more
openaire   +2 more sources

Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP

Neurobiology of Disease, 2021
Vacuolar protein sorting protein 35 (VPS35) is a core component of the retromer complex involved in regulating protein trafficking and retrieval. Recently, a missense mutation, Asp620Asn (D620N), in VPS35 (PARK17) has been identified as a pathogenic ...
Mei Jiang, Hai-Tao Tu, Ke Zhang, Wei Zhang, Wei-Ping Yu, Jie Xu, Eng-King Tan, Kai-Hua Guo, Li Zeng   +8 more
doaj   +1 more source

VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease

Molecular Neurodegeneration, 2023
Background Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-onset, autosomal dominant Parkinson’s disease (PD), with a single missense mutation (Asp620Asn, D620N) known to segregate with disease in families with PD. The VPS35
Xi Chen, Elpida Tsika, Nathan Levine, Darren J. Moore   +3 more
doaj   +1 more source

ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells

Scientific Reports, 2022
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that regulates endosomal trafficking in eukaryotic cells. Recent studies have shown that VPS35 promotes tumor cell proliferation and affects the nuclear accumulation of its ...
Xian Hong, Tao Wang, Juan Du, Yu Hong, Cai-Ping Yang, Wei Xiao, Yang Li, Ming Wang, He Sun, Zhi-Hui Deng   +9 more
doaj   +1 more source

Parkinson’s Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread

Cells, 2021
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, characterized by progressive loss of dopaminergic neurons in the substantia nigra, intraneuronal deposition of misfolded proteins known as Lewy bodies, and chronic ...
Yingzhuo Ding, Yan Li, Gaurav Chhetri, Xiaoxin Peng, Jing Wu, Zejian Wang, Bo Zhao, Wenjuan Zhao, Xueyi Li   +8 more
doaj   +1 more source

VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease [PDF]

Aging Cell, 2021
Abstract D620N mutation in the vacuolar protein sorting 35 ortholog (VPS35) gene causes late‐onset, autosomal dominant familial Parkinson's disease (PD) and contributes to idiopathic PD. However,
Mengyue Niu, Fanpeng Zhao, Karina Bondelid, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Wenzhang Wang, Jun Liu, Xiongwei Zhu   +8 more
openaire   +2 more sources

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways [PDF]

, 2016
A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents of a large number of human cancers, of which cervical is the most common.
Banks, Lawrence, Ganti, Ketaki, John, Doorbar, Kranjec, Christian, Lizano, Marcela, Manzo-Merino, Joaquin, Massimi, Paola, Pim, David, Playford, Martin P, Roberts, Sally, Tomaić, Vjekoslav   +10 more
core   +5 more sources

Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition

Molecular Brain, 2021
Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson’s disease.
Chelsie A. Kadgien, Anusha Kamesh, Austen J. Milnerwood   +2 more
doaj   +1 more source

LRRK2 as a Potential Disease-Modifying Target in Sporadic Parkinson's Disease. [PDF]

Mov Disord
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Lang AE, Hauser RA, Kalia LV, Hersh B, Berger Z, Arenas RL, Paisan-Ruiz C, Fraser K, Jennings D, Kluss JH, Huntwork-Rodriguez S, Henry AG, Greenamyre JT.   +12 more
europepmc   +2 more sources

VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function

Cell Reports, 2015
Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal trafficking. Mutations of VPS35 have been linked to familial Parkinson’s disease (PD).
Fu-Lei Tang, Wei Liu, Jin-Xia Hu, Joanna Ruth Erion, Jian Ye, Lin Mei, Wen-Cheng Xiong   +6 more
doaj   +1 more source