Role of the VPS35 D620N mutation in Parkinson's disease [PDF]
Parkinsonism & Related Disorders, 2017 Parkinson's disease (PD) is a neurodegenerative disorder involving the loss of dopaminergic neurons in the brain. Following the discovery of the PD-causing D620N mutation in the VPS35 (Vacuolar sorting protein 35) gene, dysfunction in the subcellular retromer complex has been strongly implicated in pathogenesis of PD.
Megha Mohan, George D. Mellick
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αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]
, 2017 The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías +12 more
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Linking the VPS35 and EIF4G1 Pathways in Parkinson’s Disease [PDF]
Neuron, 2015 Elucidating the underlying pathogenic pathways in Parkinson's disease will be critical for targeted drug development. In this issue of Neuron, Dhungel et al. (2015) utilize a yeast model to establish a link between VPS35 and EIF4G1 in α-synuclein-related neurodegeneration.
Ross, Owen A. +2 more
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VPS35 Protects Against TMEM230-mutation-induced Progressive Locomotor Deficits in Drosophila [PDF]
Neuroscience Bulletin, 2021 Abstract BackgroundRecently, four Parkinson’s disease (PD)-linked mutations (Y92C, R141L, 184PGext*5 and 184Wext*5) in transmembrane protein 230 (TMEM230) were identified in PD patients, and these mutations have implications in protein trafficking and neurodegeneration.
Chao Ma +3 more
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Understanding the contributions of VPS35 and the retromer in neurodegenerative disease
Neurobiology of Disease, 2022 Perturbations of the endolysosomal pathway have been suggested to play an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD).
Erin T. Williams +3 more
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Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation? [PDF]
, 2018 The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this
Arighi +30 more
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VPS35 regulates tau phosphorylation and neuropathology in tauopathy.
Molecular psychiatry, 2021 The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset Alzheimer's disease.
Vagnozzi, Alana N. +6 more
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VPS35 depletion does not impair presynaptic structure and function [PDF]
Scientific Reports, 2018 AbstractThe endosomal system is proposed as a mediator of synaptic vesicle recycling, but the molecular recycling mechanism remains largely unknown. Retromer is a key protein complex which mediates endosomal recycling in eukaryotic cells, including neurons.
Sonia Vazquez-Sanchez +4 more
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Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing [PDF]
, 2018 The processing of amyloid precursor protein (APP) to the neurotoxic pro-aggregatory Aβ peptide is controlled by the mechanisms that govern the trafficking and localisation of APP.
Breusegem, Sophia +2 more
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Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice
Molecular Brain, 2020 Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network.
Sarivin Vanan +13 more
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