Results 71 to 80 of about 7,193 (199)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Induced pluripotent stem cell line (LCSBi001-A) derived from a patient with Parkinson's disease carrying the p.D620N mutation in VPS35

Stem Cell Research, 2020
Fibroblasts were obtained from a 76 year-old man diagnosed with Parkinson's disease (PD). The disease is caused by a heterozygous p.D620N mutation in VPS35.
Simone B. Larsen, Zoé Hanss, Gérald Cruciani, François Massart, Peter A. Barbuti, George Mellick, Rejko Krüger   +6 more
doaj   +1 more source

The making of a mammalian peroxisome, version 2.0: mitochondria get into the mix [PDF]

, 2017
This is the author accepted manuscript. The final version is available from Nature Publishing Group via the DOI in this record.A recent report from the laboratory of Heidi McBride (McGill University) presents a role for mitochondria in the de novo ...
A Bagattin, A Sood, A Sugiura, A Sugiura, A van der Zand, AC Muntau, AM Motley, AM Motley, AM Pickrell, B Knoblach, C Williams, D Hoepfner, D Matheoud, E Area-Gomez, E Area-Gomez, E Braschi, EH Hettema, FC Klouwer, G Agrawal, GL McLelland, GL McLelland, HK Delille, HW Platta, J Berger, J Koch, JA Kiel, JE Vance, JE Vance, JE Vance, JJ Smith, JL Costello, K Knoops, KA Sacksteder, Luca Pellegrini, M Giacomello, M Honsho, M Neuspiel, M Schrader, M Schrader, M Schrader, Michael Schrader, MS Herrera-Cruz, NA Bonekamp, NE Braverman, PB Lazarow, PK Kim, R Erdmann, R Hua, R Hua, R Rucktaschel, R Stoica, RJ Wanders, S Caielli, S Goldfischer, S Vyas, S Yamashita, SJ Gould, SJ Huybrechts, T Matsuzaki, V Soubannier, W Yuan   +60 more
core   +1 more source

Motor and Cognitive Outcome After Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson's Disease Harboring GBA1 Variant

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) is effective for Parkinson's disease (PD); however, its efficacy varies with genetic background, such as the GBA1 variant—the causative gene of Gaucher disease—associated with increased PD risk and cognitive decline after subthalamic nucleus (STN)‐DBS.
Hikaru Kamo, Genko Oyama, Mai Shimizu, Haruka Takeshige‐Amano, Takashi Ogawa, Wataru Sako, Noriko Nishikawa, Taku Hatano, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Masanobu Ito, Hirokazu Iwamuro, Atsushi Umemura, Nobutaka Hattori   +14 more
wiley   +1 more source

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Molecular Neurodegeneration, 2020
Background The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP metabolism and
Jian-Guo Li, Jin Chiu, Mercy Ramanjulu, Benjamin E. Blass, Domenico Praticò   +4 more
doaj   +1 more source

Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. [PDF]

, 2015
Notch signaling is a major regulator of cell fate, proliferation, and differentiation. Like other signaling pathways, its activity is strongly influenced by intracellular trafficking.
Bray, Sarah J, Gomez-Lamarca, Maria J, Klein, Thomas, Seib, Ekatarina, Snowdon, Laura A   +4 more
core   +1 more source

VPS35, the core component of the retromer complex, and Parkinson's disease

Ibrain, 2021
Parkinson's disease (PD) is a neurodegenerative disease that is common in middle‐aged and elderly people, and its onset is related to multiple factors, such as heredity, environment, and age.
Ai‐Di Luo, Zu‐Cai Xu, Shu‐Sheng Liao   +2 more
doaj   +1 more source

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50 [PDF]

, 2016
Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs
Cullen, Peter J., Dengjel, Jörn, Diedrich, Britta, Heesom, Kate J., Kvainickas, Arunas, Nägele, Heike, Orgaz, Ana Jimenez, Steinberg, Florian   +7 more
core   +2 more sources

Impact of Alcohol Intake on Parkinson's Disease Risk and Progression: A Systematic Review and Dose–Response Meta‐Analysis of Prospective Studies

Movement Disorders, EarlyView.
Abstract The association between alcohol consumption and Parkinson's disease (PD) risk remains unclear, whereas smoking has an inverse relationship with the disease. This study systematically reviewed and meta‐analyzed 16 studies (2014–2024) from PubMed, Scopus, Web of Science, MEDLINE, and the Cochrane Library to assess the relationship between ...
Sahar Hemeda, Mohammed Elmadani, Mohammed Merzah, Aseel Odeh, Evelyn Pintér, István Balás, József Janszky, Dávid Pintér, Norbert Kovács   +8 more
wiley   +1 more source