Results 81 to 90 of about 7,193 (199)
Biology Open, 2012 Summary VPS35, a major component of the retromer, plays an important role in the selective endosome-to-Golgi retrieval of membrane proteins. Dysfunction of retromer is a risk factor for neurodegenerative disorders, but its function in developing mouse ...
Chun-Lei Wang +5 more
doaj +1 more source
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]
, 2016 The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H. +5 more
core +1 more source
Cellular processes associated with LRRK2 function and dysfunction. [PDF]
, 2015 Mutations in the leucine-rich repeat kinase 2 (LRRK2) encoding gene are the most common cause of monogenic Parkinson's Disease (PD). The identification of LRRK2 polymorphisms associated with increased risk for sporadic PD, as well as the observation that
Bandopadhyay, R, Manzoni, C, Wallings, R
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT High temperature has posed significant challenges to global agriculture, markedly leading to reduced fertility and yield losses in tomato (Solanum lycopersicum). Therefore, thermotolerance‐conferring genes and loci are needed to further improve cultivated tomatoes.
Xiaolin Geng +9 more
wiley +1 more source
VPS35 and retromer dysfunction in Parkinson's disease
Philosophical Transactions of the Royal Society B: Biological SciencesThe vacuolar protein sorting 35 ortholog ( VPS35 ) gene encodes a core component of the retromer complex essential for the endosomal sorting and recycling of transmembrane cargo. Endo-lysosomal pathway deficits are suggested to play a role in the pathogenesis of neurodegenerative diseases ...
Jordan Rowlands, Darren J. Moore
openaire +2 more sources
Neural Regeneration Research, 2022 SNCA, GBA, and VPS35 are three common genes associated with Parkinson’s disease. Previous studies have shown that these three genes may be associated with Alzheimer’s disease (AD).
Ya-Fei Wen +12 more
doaj +1 more source
Understanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt
Annals of Neurology, Volume 99, Issue 3, Page 566-587, March 2026.[Color figure can be viewed at www.annalsofneurology.org] As the population ages, certain neurodegenerative diseases (NDs) are becoming a major health issue. For this reason, this review will focus on the most common ND with onset after 65 years old; Alzheimer's disease, Parkinson's disease, Lewy body dementia, and frontotemporal dementia.
Laura Ibanez +5 more
wiley +1 more source
Frequency of the D620N Mutation in VPS35 in Parkinson Disease [PDF]
Archives of Neurology, 2012 To evaluate the frequency and clinical spectrum of the recently identified p.D620N mutation in the VPS35 gene in Parkinson disease (PD) in an international sample.Genetic analysis by DNA sequencing and detailed clinical and neuropsychiatric assessment as well as neuroimaging in mutation carriers.Tertiary referral centers in Germany, Serbia, Chile, and ...
Kishore R, Kumar +15 more
openaire +2 more sources
Translational Neurodegeneration, 2021 Background Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PARK2 (encoding the E3 ubiquitin ...
Kai Yu Ma +4 more
doaj +1 more source
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways [PDF]
, 2017 Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (α-syn), a protein ...
Auluck, Pavan K. +29 more
core +1 more source