Results 111 to 120 of about 6,175 (141)

Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns. [PDF]

open access: yesACS Chem Biol
Fedorova O   +5 more
europepmc   +1 more source

Pioneering role of RNA in the early evolution of life. [PDF]

open access: yesGenet Mol Biol
Muñoz-Velasco I   +6 more
europepmc   +1 more source

Rfam 15: RNA families database in 2025

open access: yes
Ontiveros N   +9 more
europepmc   +1 more source

Folding and catalysis by the VS ribozyme

Biochimie, 2002
The VS ribozyme is a 154 nt self-cleaving RNA molecule that can be divided into a trans-acting five-helix ribozyme and stem-loop substrate. The structure of the ribozyme is organised by two three-way helical junctions, the structure of which has been determined by a combination of comparative gel electrophoresis and fluorescence resonance energy ...
Lafontaine, Daniel A.   +2 more
openaire   +4 more sources

Trans Hammerhead Ribozyme: Ligation vs. Cleavage [PDF]

open access: possible, 2007
Trans hammerhead ribozymes are considered from the point of view of the RNA world theory. An attempt was made to reconstruct the ‘ancestors’ of contemporary hammerhead ribozymes with improved ligation activity by altering the sequence of trans hammerhead motifs.
Valentin V. Vlassov   +3 more
openaire   +1 more source

Efficient, pH-Dependent RNA Ligation by the VS Ribozyme in Trans

Biochemistry, 2003
The VS ribozyme acts as a very efficient ligase in trans when the 5' cleavage product is prevented from dissociation by an extended helix Ia in the substrate. Provided that the length of this helix is >or=10 bp, the substrate becomes approximately 80% ligated by the ribozyme acting in trans.
Aileen C. Mcleod, David M.J. Lilley
openaire   +3 more sources

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