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Mitochondrial transport of catalytic RNAs and targeting of the organellar transcriptome in human cells. [PDF]
Głodowicz P+4 more
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Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns. [PDF]
Fedorova O+5 more
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A CRISPR homing screen finds a chloroquine resistance transporter-like protein of the Plasmodium oocyst essential for mosquito transmission of malaria. [PDF]
Balakrishnan A+5 more
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Therapeutic applications of RNA nanostructures. [PDF]
Yip T, Qi X, Yan H, Chang Y.
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ARTEMIS: a method for topology-independent superposition of RNA 3D structures and structure-based sequence alignment. [PDF]
Bohdan DR, Bujnicki JM, Baulin EF.
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Pioneering role of RNA in the early evolution of life. [PDF]
Muñoz-Velasco I+6 more
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Folding and catalysis by the VS ribozyme
Biochimie, 2002The VS ribozyme is a 154 nt self-cleaving RNA molecule that can be divided into a trans-acting five-helix ribozyme and stem-loop substrate. The structure of the ribozyme is organised by two three-way helical junctions, the structure of which has been determined by a combination of comparative gel electrophoresis and fluorescence resonance energy ...
Lafontaine, Daniel A.+2 more
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Trans Hammerhead Ribozyme: Ligation vs. Cleavage [PDF]
Trans hammerhead ribozymes are considered from the point of view of the RNA world theory. An attempt was made to reconstruct the ‘ancestors’ of contemporary hammerhead ribozymes with improved ligation activity by altering the sequence of trans hammerhead motifs.
Valentin V. Vlassov+3 more
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Efficient, pH-Dependent RNA Ligation by the VS Ribozyme in Trans
Biochemistry, 2003The VS ribozyme acts as a very efficient ligase in trans when the 5' cleavage product is prevented from dissociation by an extended helix Ia in the substrate. Provided that the length of this helix is >or=10 bp, the substrate becomes approximately 80% ligated by the ribozyme acting in trans.
Aileen C. Mcleod, David M.J. Lilley
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