Results 91 to 100 of about 28,021 (274)
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators
British Journal of Pharmacology, EarlyView.Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo +6 more
wiley +1 more source
Clinical Genetics, EarlyView.We set out to characterize genotype–phenotype correlations in the recently delineated KDM2B‐associated neurodevelopmental disorder. We observe a highly penetrant CxxC domain‐related phenotype with distinct facial features supported by GestaltMatcher. In contrast, our findings point to variable expressivity and incomplete penetrance of loss‐of‐function ...
Amber S. E. van Oirsouw +30 more
wiley +1 more source
Siemens Profibus System: For teaching purposes
, 2013 Throughout the Industrial Computer Systems Engineering course students have only been exposed to SCADA and industrial communications through research and limited practical applications. The Siemens WinCC and Profibus SCADA System described in this report
Martens, Jonty
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Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development
Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah +8 more
wiley +1 more source
The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management
Journal of Paediatrics and Child Health, EarlyView.ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley +3 more
wiley +1 more source
Gomal Journal of Medical Sciences, 2014 Background: Pulmonary artery banding is a palliative surgical procedure used as a staged-approach to operative correction of congenital heart defects leading to right ventricular volume overload and pulmonary hypertension.
Muhammad Aasim +7 more
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Case Reports in Cardiology, 2012 Finding an untreated or asymptomatic large ventricular septal defect (VSD) in an elderly patient is uncommon. The present case was an 81-year-old man who suffered from acute myocardial infarction due to three-vessel coronary disease, mitral and tricuspid
Eiki Tayama +6 more
doaj +1 more source
Transcatheter device closure of a traumatic ventricular septal defect
Annals of Pediatric Cardiology, 2014 A traumatic ventricular septal defect (VSD) resulting from blunt chest injury is a very rare event in children. The clinical symptoms and timing of presentation are variable, so diagnosis and management of traumatic VSD may be challenging.
Mohamed Kasem +4 more
doaj +1 more source
A Generic Simulink Model Template for Simulation of Small Satellites
, 2009 This paper presents a template architecture for a straightforward specification of small satellite missions by means of a domain specific language.
Gerndt, Andreas +4 more
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