Results 61 to 70 of about 201,485 (360)
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Nature Chemical Biology, 2019 Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a ...
W. Farnaby +36 more
semanticscholar +1 more source
Reducing uncertainties of climate projections on solar energy resources in Brazil
Scientific ReportsThe share of solar power in Brazil’s electrical grid has rapidly increased, relieving GHG emissions and diversifying energy sources for greater energy security.
Francisco José Lopes de Lima +7 more
doaj +1 more source
Journal of Hydrology: Regional Studies, 2019 Study region: The Upper Niger and Bani River basins in West Africa. Study focus: The growing demand for food, water, and energy led Mali and Guinea to develop ambitious hydropower and irrigation plans, including the construction of a new dam and the ...
Stefan Liersch +10 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Legal and human rights issues of AI: Gaps, challenges and vulnerabilities
, 2020 This article focusses on legal and human rights issues of artificial intelligence (AI) being discussed and debated, how they are being addressed, gaps and challenges, and affected human rights principles.
Rowena Rodrigues
semanticscholar +1 more source
STRATEGIC ANALYSIS OF UKRAINE’S SECURITY ENVIRONMENT
Стратегічна панорама, 2022 The article reports on the results of a strategic analysis of Ukraine's security environment based on a SWOT analysis. The focus is on the security environment as of the eve of the large-scale war launched by the Russian Federation against Ukraine in ...
Olga Reznikova
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Security vulnerabilities of popular smart home appliances [PDF]
, 2021 A Smart Home essentially is a communication network that connects smart devices, sensors and actuators enabling the owner to locally and remotely access, monitor and control them.
Hussain, F., Qi, M., Induruwa, A.
core
Number of vulnerabilities, number of exploited vulnerabilities, the fraction of exploited vulnerabilities that appeared in each source. [PDF]
, 2020 Number of vulnerabilities, number of exploited vulnerabilities, the fraction of exploited vulnerabilities that appeared in each source.
Yong Fang (301344) +3 more
core +1 more source