Results 81 to 90 of about 128,229 (266)
JàmbáThe increasing frequency of hazards such as floods, droughts, socio-political unrest, emerging diseases and rising temperatures has affected South Africa.
Davies V. Nkosi +9 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Supply chain resilience and measurement dimensions: The case of halal pharmaceuticals in Malaysia
SHS Web of Conferences, 2018 Resilience is the vital feature of supply chains that confers the ability to withstand the adverse effects of disruptive events. Most of the previous studies have been conceptual, theoretical, normative, or at best qualitative in approach, concentrating ...
Aigbogun Osaro +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Artificial intelligence tools for automating penetration testing
Технічна інженеріяThe article discusses automated penetration testing using artificial intelligence (AI), which significantly enhances the efficiency and accuracy of cybersecurity assessments.
M.S. Koloshchuk +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Ontological model for predicting cyberattacks based on virtualized Honeynets
Logos Ciencia & Tecnología, 2016 The honeynets security tools are widely used today for the purpose of gathering information from potential attackers about vulnerabilities in our network. For performing correct use of them is necessary to understand the existing types, structures raised,
Gaona-García, Pablo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Less vulnerable valuation of vulnerable options
Annals of Operations ResearchAbstract In this article, closed form exact formulae are provided for two-asset vulnerable options with continuous default risk and partial recovery, stochastic default boundary, stochastic interest rate and jump-diffusion dynamics of the underlying assets. The single asset case is also covered.
openaire +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source