Results 51 to 60 of about 1,382,065 (344)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Mental health of undocumented migrants and migrants undergoing regularization in Switzerland: a cross-sectional study

BMC Psychiatry, 2021
Background Undocumented migrants live and work in precarious conditions. Few studies have explored the mental health consequences of such environment.
Julien Fakhoury, Claudine Burton-Jeangros, Liala Consoli, Aline Duvoisin, Delphine Courvoisier, Yves Jackson   +5 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Does parent-child connectedness influence substance use among Bhutanese adolescents: evidence from a national survey?

BMC Public Health
Highlights • Tobacco use was highest, followed by alcohol and marijuana use. • The prevalence of substance use was higher in male than female adolescents.
Md. Tanvir Hasan Sojib, Md. Habibur Rahman, Md. Imamur Rashid Gogon, Md. Khalid Hasan   +3 more
doaj   +1 more source

First episode-psychosis: Short- and long-term outcomes and related features predicting the transition to schizophrenia

European Psychiatry, 2022
Introduction The occurrence of a first episode-psychosis in adolescents or young adults represents a difficult struggle with an uncertain and divergent outcome, since the clinician does not have at his disposal the clinical elements sufficient to ...
M. Jabeur, L. Gassab, S. Boughamoura, A. Mhalla, F. Zaafrane, L. Gaha   +5 more
doaj   +1 more source

Neuronal vulnerability and multilineage diversity in multiple sclerosis

Nature, 2019
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing–remitting disease course at early stages, distinct lesion characteristics in cortical grey versus subcortical white matter and neurodegeneration at chronic stages.
Lucas Schirmer, Dmitry Velmeshev, S. Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, J. Stockley, Adam M. H. Young, M. Steindel, Brian Tung, Nitasha Goyal, A. Bhaduri, Simone Mayer, J. B. Engler, O. Bayraktar, R. Franklin, M. Haeussler, R. Reynolds, D. Schafer, M. Friese, L. Shiow, A. Kriegstein, D. Rowitch   +23 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Prevalence and clinical features of anxiety disorders: Tunisian study about 436 subjects

European Psychiatry, 2022
Introduction Anxiety disorders represent one of the most common mental disorders following a chronic course. Objectives The aim of our study is to determine the prevalence, incidence and clinical characteristics of these disorders.
M. Jabeur, L. Gassab, A. Ayadi, B. Ben Mohamed, F. Zaafrane, L. Gaha   +5 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source