Results 61 to 70 of about 911,238 (315)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
WHAT VULNERABILITY? WHOSE VULNERABILITY? CONFLICT OF UNDERSTANDINGS IN THE DEBATE ON VULNERABILITY
Facta Universitatis, Series: Law and Politics, 2017 In this paper, I intend to explore the apparent difficulty in communication between two understandings of vulnerability: one that claims that vulnerability is a part of conditio humana, a feature closely connected to the facts of (human) embodiment and mortality, and the other which argues for the exclusivity of vulnerability and wishes to limit it to ...
openaire +3 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Poverty and Vulnerability - An Interdisciplinary Approach [PDF]
This paper describes the concepts of poverty and vulnerability as well as the interconnections and differences between them using an interdisciplinary approach. While poverty is a static concept, vulnerability has a forward-looking dimension.
Makoka, Donald, Kaplan, Marcus
core
, 2022 reservedStarting from the study of existing literature on the topic, the thesis elaborates on the concept of 'vulnerability'. After analyzing how such concept emerged and evolved in the legal-philosophical reflection, its main understandings in the field
SEGALA, MARIA
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SSM: Population Health, 2019 Background: Childhood misfortune is associated with late-life depressive symptoms, but it remains an open question whether adult socioeconomic and relational reserves could reduce the association between childhood misfortune and late-life depressive ...
Martina von Arx +10 more
doaj +1 more source
Proceedings of the 24th International Conference on Intelligent User Interfaces, 2019 11 pages, 7 ...
Alireza Karduni +7 more
openaire +4 more sources
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Measuring the Vulnerability of Subnational Regions [PDF]
A small but growing literature has been concerned about the economic (and environmental) vulnerability on the level of countries. Less attention is paid to the economic vulnerability of different regions within countries. By focusing on the vulnerability
Rossouw, Stephanie +2 more
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