Results 51 to 60 of about 32,051 (269)
Fire-Induced Collapse Analysis of Warehouse Structures Using FDS and Thermomechanical Modeling
BuildingsThis study investigates the fire dynamics and structural response of steel-framed warehouse racking systems under various fire scenarios, emphasizing the critical importance of fire safety measures in mitigating structural damage.
Fatih Yesevi Okur
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Vulnerability of buildings exposed to dynamic flooding.
, 2020 Repeatedly, dynamic flooding causes high loss in many mountain regions all over the world. Dynamic flooding is a group of hazard processes includingfluvial sediment transport, debris floods, and debris flows, as well as to some extent flash ...
Papathoma-Köhle, M. +2 more
core
Revista de Estudios Latinoamericanos sobre Reducción del Riesgo de Desastres, 2019 Disasters are a set of elements composed of risks, hazards, vulnerabilities, resilience and exposure. Although there often are disaster recovery funds, these are never enough to meet the needs of people.
Felipe de Jesús Juárez Villanueva
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Vulnerability elements to HIV/AIDS among adolescents: integrative review
, 2008 Introdução: A adolescência é um dos períodos mais intensos da vida, pelos desafios, descobertas e oportunidades de exploração nela presentes e, por isso, se constitui um determinante da vulnerabilidade ao HIV/AIDS.
Melina Mafra Toledo +1 more
core +1 more source
Local protection against mountain hazards – state of the art and future needs [PDF]
Natural Hazards and Earth System Sciences, 2008 During the last decades, settlement activities increased in European mountain regions. Due to the scarceness of areas suitable for development, residential estates were extended into areas endangered by natural hazards such as mass movements.
J. Hübl, M. Holub
doaj
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source