Results 71 to 80 of about 5,815,285 (328)

A GIS-Based Support Vector Machine Model for Flash Flood Vulnerability Assessment and Mapping in China

ISPRS Int. J. Geo Inf., 2019
Flash floods are one of the natural disasters that threaten the lives of many people all over the world every year. Flash floods are significantly affected by the intensification of extreme climate events and interactions with exposed and vulnerable ...
J. Xiong, Jin Li, W. Cheng, Nan Wang, Liang Guo   +4 more
semanticscholar   +1 more source

Research on key technology of vulnerability threat classification

Tongxin xuebao, 2012
In order to solve the vulnerability assessment problem of vulnerability management,three attribute groups were selected to qualitatively evaluate vulnerability threat.After the selection of vulnerability attributes,analytic hierarchy process method was ...
Qi-xu LIU, Chong-bin ZHANG, Yu-qing ZHANG, Bao-feng ZHANG   +3 more
doaj   +2 more sources

Towards a verifiable, uncertainty-controlled assessment of the spatiotemporal dynamics of social vulnerability to flash floods

Ecological Indicators
While research on quantitative measures of vulnerability is increasing, current studies may be criticized for failing to consider the spatiotemporal dynamics of vulnerability, ignoring uncertainty in the assessment process, and lacking validation.
Xinjun He, Yiping Fang, Baosheng Wang, Xueyuan Huang   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Structural Vulnerability Assessment of Heritage Timber Buildings: A Methodological Proposal

Forests, 2020
The conservation of heritage structures is pivotal not only due to their cultural or historical importance for nations, but also for understanding their construction techniques as a lesson that can be applied to contemporary structures.
A. Shabani, M. Kioumarsi, V. Plevris, Haris Stamatopoulos   +3 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Vulnerability of the agricultural sector to climate change: The development of a pan-tropical Climate Risk Vulnerability Assessment to inform sub-national decision making

PLoS ONE, 2019
As climate change continues to exert increasing pressure upon the livelihoods and agricultural sector of many developing and developed nations, a need exists to understand and prioritise at the sub national scale which areas and communities are most ...
L. Parker, C. Bourgoin, A. Martinez-Valle, P. Läderach   +3 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Seismic vulnerability assessment at urban scale using data mining and GIScience technology: application to Urumqi (China)

Geomatics, Natural Hazards & Risk, 2019
Seismic vulnerability assessments play a significant role in comprehensive risk mitigation efforts and seismic emergency planning, especially for urban areas with a high population density and a complex construction environment.
Yaohui Liu, Zhiqiang Li, Benyong Wei, Xiaoli Li, Bo Fu   +4 more
semanticscholar   +1 more source

Vulnerability Assessment of Dwelling Buildings [PDF]

, 2006
Risk is defined as the potential economic, social and environmental consequences of hazardous events that may occur in a specified area unit and period. The evaluation of physical vulnerability and risk of buildings is the main purpose of this chapter. Nevertheless, it is shown the necessity of considering not only the expected physical damage but also
Barbat, Alex, Lagomarsino, S., Pujades, L.   +2 more
openaire   +2 more sources