Results 51 to 60 of about 218,925 (253)

AN INDICATOR-BASED APPROACH FOR MICRO-SCALE PHYSICAL FLOOD VULNERABILITY MAPPING [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
Map representation of vulnerability is a crucial step in evaluating flood impact and all vulnerability indicators that are the final product of risk assessment. So far, in flood risk assessment, this is probably the weakest link.
I. U. Kaoje, M. Z. Abdul Rahman, T. H. Tam, M. R. Mohd Salleh   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Vulnerability chain assessment for multiple vulnerabilities [PDF]

Proceedings of the 2016 3rd International Conference on Materials Engineering, Manufacturing Technology and Control, 2016
The dangers of a single vulnerability can be assessed by the CVSS, but in some cases, comprehensive harm of several vulnerabilities is 1 + 1> 2. So evaluating multiple vulnerabilities that are not just many single vulnerability assessments, but also integrated many complex situations.
Sujuan Qin, Deqiang Qiu
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Towards a verifiable, uncertainty-controlled assessment of the spatiotemporal dynamics of social vulnerability to flash floods

Ecological Indicators
While research on quantitative measures of vulnerability is increasing, current studies may be criticized for failing to consider the spatiotemporal dynamics of vulnerability, ignoring uncertainty in the assessment process, and lacking validation.
Xinjun He, Yiping Fang, Baosheng Wang, Xueyuan Huang   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Research on key technology of vulnerability threat classification

Tongxin xuebao, 2012
In order to solve the vulnerability assessment problem of vulnerability management,three attribute groups were selected to qualitatively evaluate vulnerability threat.After the selection of vulnerability attributes,analytic hierarchy process method was ...
Qi-xu LIU, Chong-bin ZHANG, Yu-qing ZHANG, Bao-feng ZHANG   +3 more
doaj   +2 more sources

Development of the vulnerability assessment model of explosive terrorism in multi-use buildings

Journal of Asian Architecture and Building Engineering, 2019
The purpose of this study is to develop a vulnerability assessment model of explosive terrorism in multi-use buildings focusing mainly on architectural design elements.
Kyung-Yeon Kang, So-Yeon Park, Hong Heo, Myung-Sik Lee, Kyung-Hoon Lee   +4 more
doaj   +1 more source