Results 71 to 80 of about 900,479 (294)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Vulnerability Assessment of Dwelling Buildings [PDF]

, 2006
Risk is defined as the potential economic, social and environmental consequences of hazardous events that may occur in a specified area unit and period. The evaluation of physical vulnerability and risk of buildings is the main purpose of this chapter. Nevertheless, it is shown the necessity of considering not only the expected physical damage but also
Barbat, Alex, Lagomarsino, S., Pujades, L.   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Development of the vulnerability assessment model of explosive terrorism in multi-use buildings

Journal of Asian Architecture and Building Engineering, 2019
The purpose of this study is to develop a vulnerability assessment model of explosive terrorism in multi-use buildings focusing mainly on architectural design elements.
Kyung-Yeon Kang, So-Yeon Park, Hong Heo, Myung-Sik Lee, Kyung-Hoon Lee   +4 more
doaj   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Research on key technology of vulnerability threat classification

Tongxin xuebao, 2012
In order to solve the vulnerability assessment problem of vulnerability management,three attribute groups were selected to qualitatively evaluate vulnerability threat.After the selection of vulnerability attributes,analytic hierarchy process method was ...
Qi-xu LIU, Chong-bin ZHANG, Yu-qing ZHANG, Bao-feng ZHANG   +3 more
doaj   +2 more sources

User guide : Groundwater Vulnerability (Scotland) GIS dataset. Version 2 [PDF]

, 2011
This report describes a revised version (Version 2) of the groundwater vulnerability (Scotland) digital dataset produced by the British Geological Survey (BGS).
Doce, D.D., MacDonald, A.M., O Dochartaigh, B.E., Rutter, H.K.   +3 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Design and implementation of a vulnerability assessment system for oil and gas pipelines in Natech events

You-qi chuyun
[Objective] The oil and gas conveyed in transmission pipelines are highly flammable and explosive. During natural disasters,these pipelines are susceptible to technological accidents such as fire, explosion, and environmental pollution, i.e.
CHEN Guohua, TAO Xia, ZHOU Lixing
doaj   +1 more source