Results 61 to 70 of about 2,041,932 (309)

Introduction to Computer Network Vulnerabilities [PDF]

, 2015
System vulnerabilities are weaknesses in the software or hardware on a server or a client that can be exploited by a determined intruder to gain access to or shut down a network. Vulnerabilities exist not only in the hardware and software that constitute a computer system but also in policies and procedures, especially security policies and procedures,
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Fault and Error Tolerance in Neural Networks: A Review

IEEE Access, 2017
Beyond energy, the growing number of defects in physical substrates is becoming another major constraint that affects the design of computing devices and systems.
Cesar Torres-Huitzil, Bernard Girau
doaj   +1 more source

Identifying Cloud Computing Vulnerabilities

International Journal of Scientific Research in Science, Engineering and Technology, 2014
Cloud computing is passing through development stage and with the passage process of development, cloud is also posing with security threats, challenges and risks. Lots of security threats, risks and challenges are directly or indirectly due to vulnerabilities in cloud environment.
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

GreenBERT: A lightweight green transformer for automated prediction of software vulnerability scores

Array
Timely assessment of software vulnerabilities is critical for effective patch prioritization, yet manual Common Vulnerability Scoring System (CVSS) scoring remains slow and resource-intensive.
Seyedeh Leili Mirtaheri, Ali Kafi Tafti, Hamid Heidari Soureshjani, Andrea Pugliese   +3 more
doaj   +1 more source

IMPACTS AND CHALLENGES OF CLOUD COMPUTING FOR SMALL AND MEDIUM SCALE BUSINESSES IN NIGERIA [PDF]

Journal of Advances in Computer Engineering and Technology, 2019
Cloud computing technology is providing businesses, be it micro, small, medium, and large scale enterprises with the same level playing grounds. Small and Medium enterprises (SMEs) that have adopted the cloud are taking their businesses to greater ...
Scholastica Mallo, Francisca Ogwueleka
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Poverty and Vulnerability - An Interdisciplinary Approach [PDF]

This paper describes the concepts of poverty and vulnerability as well as the interconnections and differences between them using an interdisciplinary approach. While poverty is a static concept, vulnerability has a forward-looking dimension.
Makoka, Donald, Kaplan, Marcus
core