Results 31 to 40 of about 6,654,991 (280)

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

open access: yesBiological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino   +7 more
wiley   +1 more source

Association of Urinary pH With Overall Survival in Patients With Stage IV Cancer: A Single‐Center Retrospective Cohort Study

open access: yesCancer Nexus, EarlyView.
ABSTRACT Objective This single‐center retrospective cohort study evaluated whether, among patients with stage IV cancer who participated in a pragmatic “alkalization therapy”—defined as a low potential renal acid load diet plus oral sodium bicarbonate and/or potassium/sodium citrate—urinary pH was associated with long‐term survival.
Shion Kachi   +5 more
wiley   +1 more source

Manejo quirúrgico y Test de wada en la epilepsia refractaria del lóbulo temporal

open access: yesActa Neurológica Colombiana, 2005
INTRODUCCIÓN: a pesar del manejo anticonvulsivo adecuado, hasta 40% de los pacientes persisten con crisis y 20% de ellos tienen resistencia total a los medicamentos.
Marta E. Jiménez J   +13 more
doaj   +2 more sources

Dissociated Crossed Speech Areas in a Tumour Patient

open access: yesCase Reports in Neurology, 2017
In the past, the eloquent areas could be deliberately localised by the invasive Wada test. The very rare cases of dissociated crossed speech areas were accidentally found based on the clinical symptomatology.
Jörg Mauler   +8 more
doaj   +1 more source

Exposure–Response Analysis of Enfortumab Vedotin Plus Pembrolizumab as First‐Line Therapy for Locally Advanced or Metastatic Urothelial Cancer

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Enfortumab vedotin is a nectin‐4‐directed antibody–drug conjugate currently approved in combination with pembrolizumab for the first‐line treatment of locally advanced or metastatic urothelial cancer. Here we describe the exposure–response relationship between enfortumab vedotin exposures and efficacy/safety endpoints in patients who received ≥1 dose ...
Vaishali L. Chudasama   +9 more
wiley   +1 more source

The impact of cannabis use on intracarotid amobarbital testing

open access: yesEpilepsy & Behavior Reports, 2019
Chronic cannabis use impacts memory functioning, even while users are not acutely intoxicated. The impact of cannabis use on Wada or intracarotid amobarbital testing (IAT) has not previously been described.
Christopher H. Domen   +3 more
doaj   +1 more source

Quantification of the Carboxylated LGD‐4033 Long‐Term Metabolite in Human Micro‐Dose Excretion Study Urine Samples

open access: yesDrug Testing and Analysis, EarlyView.
A validated LC‐HRMS/MS method enabled the first quantitative determination of the LGD‐4033 long‐term metabolite (M5‐b) in urine following controlled micro‐dose administration. The generated urinary reference data support the interpretation of adverse analytical findings and anti‐doping result management. ABSTRACT Selective androgen receptor modulators (
Panagiotis Sakellariou   +7 more
wiley   +1 more source

The Wada test in the evaluation for epilepsy surgery

open access: yesNeurosciences, 2000
The Wada test is the standard part of the pre-operative evaluation for epilepsy surgery. The procedure involves the slow injection of sodium amobarbital (typically 100-500mg) into the internal carotid artery following a transfermoral approach. The amobarbital anesthetizes the anterior two-thirds of the ipsilateral cerebral hemisphere for approximately ...
D W, Loring, K J, Meador, M, Westerveld
openaire   +2 more sources

Antidepressant Misuse in Esports: A Review of Pharmacology, Adverse Effects, Pharmacokinetics and Biomatrix‐Based Detection for Anti‐Doping Applications

open access: yesDrug Testing and Analysis, EarlyView.
This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum   +4 more
wiley   +1 more source

Global Practical Authority. An Analysis Through the Case of WADA

open access: yesProblema: Anuario de Filosofía y Teoría del Derecho
In the last decades, the global relevance of the World Anti-Doping Agency (WADA) has been steadily rising, through both the widespread global adoption of the WADA Code by sport organizations and public authorities and its role in establishing of ...
Miodrag Jovanović, Julieta A. Rabanos
doaj   +1 more source

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