Results 231 to 240 of about 39,272 (299)

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

open access: yesEpilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden   +5 more
wiley   +1 more source

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor   +7 more
wiley   +1 more source

Riverscape heterogeneity shapes population diversity for a migratory fish. [PDF]

open access: yesEcol Appl
Baldock JR   +5 more
europepmc   +1 more source

What Is Needed to Create a Prosocial Classroom? The Effectiveness of the Dutch Meaningful Roles Program in Children: A Cluster Randomized Controlled Study

open access: yesJournal of Adolescence, EarlyView.
ABSTRACT Introduction Having a prosocial classroom climate is crucial for promoting children's school and psychological well‐being, as well as in optimizing an effective learning environment. School‐based programs can foster more prosocial classroom climates, but few evidence‐based options are available.
Amanda W. G. van Loon   +1 more
wiley   +1 more source

Positive Peer Group Affiliation, Puberty, and Social and Emotional Development: A Strength‐Based Approach

open access: yesJournal of Adolescence, EarlyView.
ABSTRACT Introduction During the pubertal transition, peer relationships become increasingly salient for adolescents' social and emotional development. However, research on peer contexts during this period has largely emphasized deviant peer groups, leaving the potential role of positive peer affiliations less understood.
Rona Carter, Joonyoung Park
wiley   +1 more source

A Thematic Analysis Exploring Bowel Cancer Screening Promotional Visuals in the United Kingdom and India. [PDF]

open access: yesHealth Lit Res Pract
Yfantidou I   +8 more
europepmc   +1 more source

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