Results 31 to 40 of about 65,084 (258)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

DISTRIBUTED DYNAMIC PDE-MODEL OF PROGRAM CONTROL BY UTILIZATION OF THE TECHNOLOGICAL EQUIPMENT OF PRODUCTION LINE

Nauka ta progres transportu, 2019
Purpose. The article is aimed at designing a control system for the parameters of a production line for an enterprise with a straight flow method of organizing production. Methodology.
G. K. Kozevnikov, O. M. Pihnastyi
doaj   +1 more source

INVESTIGATING FOR 3D TURKEY CADASTRE WITH INTERNATIONAL STANDARDS [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
Nowadays, a very active research area is the 3D cadastre concept. In relation, 3D Cadastre is an essential component used in a land management system which is to manage and represent layered rights digitally, restrictions, responsibilities (legal models),
M. Alkan, H. G. Sürmeneli
doaj   +1 more source

A discrete-event simulation model for the analysis of a waiting line system in port services: A case study

Ingeniare. Revista chilena de ingeniería, 2022
La teoría de colas es un conjunto de modelos matemáticos que explican los sistemas en los que los clientes esperan en fila para recibir el servicio bajo criterios de selección específicos. Los modelos permiten analizar el comportamiento del sistema y encontrar un "estado sólido" que logre un uso óptimo de los recursos.
Alexander D. Pulido-Rojano, Arnaldo Verdeza-Villalobos, Brandon Martínez-Jiménez, Kemelys Pérez-De-Ávila, Diana Castellanos-Benítez, José Sarmientopérez-Polo, Paola Pulido-Rojano   +6 more
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Simulation of a bus line queuing system. [PDF]

مطالعات مدیریت بهبود و تحول, 2002
One  of the  most  important  problems   that  managers   face,  is  supplying, allocating and  using the  limited  resources  to achieve  the  best performance. Managers  of urban   transporting  systems  face  such  problems   too.  These systems  not 
kamran feizi, ahmad allah yari
doaj  

Molecular Dynamics Studies of Shape Memory Polymers: From Bead–Spring Models to Atomistic Simulations

Advanced Engineering Materials, EarlyView.
Coarse‐grained (left) and atomistic (right) models of the shape memory polymer ESTANE ETE 75DT3 are shown schematically. The two representations bridge molecular detail and mesoscopic description. Both models capture shape memory behavior, linking segmental mobility and conformational relaxation of anisotropic chains to macroscopic recovery, and ...
Fathollah Varnik
wiley   +1 more source

Proposal for improvement to reduce waiting times by means of a Mathematical-Computational Model of Waiting Lines

Ecuadorian Science Journal, 2021
In this article, a solution is proposed through a mathematical model applied to the urban taxi service that goes to “Cantón Durán”, from the city of Guayaquil. Applying a queuing theory model. It is determined whether the way in which the taxi service is currently offered to users is the most indicated with respect to the time that passengers must wait
Lara Gavilánez, Héctor R., Naranjo Peña, Irma E., Arteaga Yaguar, Elvis R., Lara Gavilánez, Héctor R., Naranjo Peña, Irma E., Arteaga Yaguar, Elvis R.   +5 more
openaire   +1 more source