Results 71 to 80 of about 90,617 (227)

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Detection of interictal epileptiform discharges using multiple bilateral insertions of a newly developed microcatheter‐compatible endovascular electroencephalogram electrode: A clinical feasibility trial

Epilepsia Open, EarlyView.
Abstract Objective To assess the feasibility, technical performance, and safety of a novel endovascular electroencephalogram (eEEG) electrode, EP‐01, designed for minimally invasive seizure localization in patients with drug‐resistant epilepsy. Methods This single‐center, prospective, exploratory trial enrolled five patients with drug‐resistant ...
Kota Araki, Yosuke Masuda, Ayataka Fujimoto, Mitsuyo Nishimura, Hisayuki Hosoo, Hiroki Ishida, Takashi Enokizono, Kensuke Kawai, Eiichi Ishikawa, Yuji Matsumaru   +9 more
wiley   +1 more source

Fenfluramine in SCN1A‐related GEFS+: A multicenter observational study on efficacy, EEG improvement, and tolerability

Epilepsia Open, EarlyView.
Abstract The SCN1A gene is implicated in a broad spectrum of epilepsy phenotypes, ranging from self‐limited genetic epilepsy with febrile seizures plus (GEFS+) to severe developmental and epileptic encephalopathies such as Dravet syndrome (DS). While fenfluramine (FFA) has demonstrated strong efficacy in DS, its role in SCN1A‐related epilepsies beyond ...
Giovanni B. Dell'Isola, Alice Muda, Lucio Giordano, Renzo Guerrini, Alessandra Boncristiano, Nicola Pietrafusa, Maria Polselli, Francesca Bisulli, Francesca Ragona, Antonella Riva, Pasquale Striano, Domenica Immacolata Battaglia, Federico Vigevano   +12 more
wiley   +1 more source

Sleep enhances gamma oscillations in the seizure onset zone and broadband activity in the irritative zone of focal cortical dysplasia

Epilepsia Open, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a leading cause of drug‐resistant epilepsy and is associated with sleep‐related seizures, yet the underlying electrophysiological mechanisms during different brain states remain poorly understood. We investigated whether fast oscillations (FOs) within the seizure onset zone (SOZ) and irritative zone (
Mohammad F. Khazali, Nina Schwoon, Armin Brandt, Matthias Dümpelmann, Yiwen Li Hegner, Nicolas Roehri, Dirk‐Matthias Altenmüller, Victoria San Antonio‐Arce, Peter C. Reinacher, Julia M. Nakagawa, Soroush Doostkam, Theo Demerath, Horst Urbach, Andreas Schulze‐Bonhage, Marcel Heers   +14 more
wiley   +1 more source

Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase–amplitude coupling

Epilepsia Open, EarlyView.
Abstract Objective Treatment selection for infantile epileptic spasms syndrome (IESS) is complex and multifaceted, and currently no electroencephalogram (EEG) biomarkers can guide this decision by predicting treatment response. We tested the predictive value of phase–amplitude coupling (PAC) as IESS patients are known to have elevated PAC.
Soudeh Mostaghimi, Marco A. Pinto‐Orellana, Nathaniel Green, Daniel W. Shrey, Makoto Miyakoshi, Shaun A. Hussain, Beth A. Lopour   +6 more
wiley   +1 more source

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

Epilepsia Open, EarlyView.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs. [PDF]

, 2019
One output arm of the sleep homeostat in Drosophila appears to be a group of neurons with projections to the dorsal fan-shaped body (dFB neurons) of the central complex in the brain.
Elsheikh, Ahmed, Gurav, Adishthi S, Hackbart, Hannah, Liu, Weiwei, Montell, Craig, Ni, Jinfei D, Ogunmowo, Tyler H, Verdegaal, Andrew A   +7 more
core   +1 more source

Anthropologist, heal thyself: Toward an anthropology of healing through relational interbeing

Feminist Anthropology, EarlyView.
Abstract I call for an anthropology that confronts its own woundedness. Anthropologists often bear witness to suffering but rarely examine how our own grief, trauma, and institutional distress shape the affective tone of our work. Drawing on fieldwork with Runa (Quechua) women affected by forced sterilization in Peru and guided by my collaborator and ...
Lucía Isabel Stavig
wiley   +1 more source

Making care audible: Musical gifts and affective reciprocity in the clinic

Feminist Anthropology, EarlyView.
Abstract In clinical settings, music therapy is frequently received as a gift—a voluntary offering that invites but does not demand participation. Drawing on ethnographic research with music therapists and patients in Canadian and American hospitals, this article examines how clinical care is co‐constituted through practices of giving, receiving, and ...
Meredith Evans
wiley   +1 more source

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

Ibrain, Volume 11, Issue 1, Page 32-43, Spring 2025.
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley   +1 more source