Results 151 to 160 of about 13,427,618 (297)

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Annals of Neurology, EarlyView.
Objective As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC).
Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang, Jie Luo, Yuan Mu, Ting Wang, Yuqing Wu, Jingping Liu, Yunyun Ning, Xuan Deng, Ming Guan, Jian Xu   +12 more
wiley   +1 more source

From Test Performance to Risk-Based Effect Sizes: A Unified Wald-Type Framework to Design Clinical Validation Studies for Binary and Survival Outcomes

Clinical validation studies of predictive tests are usually designed to focus on sensitivity ($Se$) and specificity ($Sp$), while statistical power is often calculated on regression-effect scales (e.g., risk ratio, hazard ratio). However, these quantities are statistically connected. Here, we provide closed-form links from sensitivity, specificity, and
Zhong, Yongqi, Hartman, Anne-Renee, Zhang, Jing   +2 more
openaire   +2 more sources

Centrum Semiovale Perivascular Spaces Predict First Hemorrhagic Lesion in Asymptomatic Amyloid‐Positive Individuals

Annals of Neurology, EarlyView.
Objective Identification of cerebral amyloid angiopathy (CAA) before its hemorrhagic manifestations remains limited. We aimed to determine whether severe enlarged perivascular spaces in the centrum semiovale (EPVS‐CSO) identify a prehemorrhagic stage of sporadic CAA by predicting the first appearance of CAA‐related hemorrhagic lesions or incident ...
Baris Alten, Elif Gokcal, Reisa A. Sperling, Zahra Shirzadi, Jasmeer P. Chhatwal, M. Edip Gurol, Scott E. Kasner, Steven M. Greenberg, Brett L. Cucchiara   +8 more
wiley   +1 more source

Was tragen Wald und Holz zum Klimaschutz in Deutschland bei? [PDF]

, 2016
Der Wald in Deutschland und seine nachhaltige Bewirtschaftung entlasten die Atmosphäre jährlich um 126 Mio. t CO2. Damit mindern der Wald, seine nachhaltige Bewirtschaftung und die Verwendung von Holzprodukten die deutschen Treibhausgas-Emission derzeit ...
Rüter, Sebastian, Baldauf, Thomas, Heuer, Eckhard, Schmitz, Friedrich   +3 more
core  

Neuromuscular Electric Stimulation Improves Early Isometric Knee Strength After Anterior Cruciate Ligament Reconstruction and Repair: A Meta‐analysis of Randomized Controlled Trials

Arthroscopy, EarlyView.
Purpose To assess the effectiveness of neuromuscular electrical stimulation (NMES) on quadriceps strength and knee function after anterior cruciate ligament surgery. Methods A comprehensive search of PubMed, Ovid MEDLINE, and Embase from inception until February 2025 was conducted.
Anser Daud, Darius Luke Lameire, Geoffrey William Schemitsch, Daniel Burke Whelan, Tim Dwyer, John Theodoropoulos, Jaskarndip Chahal   +6 more
wiley   +1 more source

Deucravacitinib in Active Psoriatic Arthritis: Efficacy and Safety Up to 52 Weeks From the Randomized, Double‐Blind, Phase 3 POETYK PsA‐2 Trial

Arthritis &Rheumatology, EarlyView.
Objective To assess the efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with psoriatic arthritis (PsA) who were naive to biologic disease‐modifying antirheumatic drugs or received tumor necrosis factor inhibitors. Methods In the 52‐week, double‐blind, placebo‐controlled, phase 3 Program for Evaluation
Philip J. Mease, Vinod Chandran, April W. Armstrong, Ricardo Blanco, Alexis Ogdie, Evan L. Siegel, Alice B. Gottlieb, Xiaofeng Zeng, Diamant Thaçi, Mitsumasa Kishimoto, Hendrik Schulze‐Koops, Alan Kivitz, Eva Dokoupilová, Akimichi Morita, Eric M. Ruderman, Michael Plewinski, Kejia Wang, Caroline Sardinas, Eleni Vritzali, John Vaile, Atul Deodhar   +20 more
wiley   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging

Arthritis &Rheumatology, EarlyView.
Objective The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing in vastus lateralis muscle, resulting in 523 participants (56% female).
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

Minimal virtual reality‐induced symptoms and effects in anatomy education across controller types

Anatomical Sciences Education, EarlyView.
Abstract With the increasing adoption of virtual reality (VR) in anatomy education, understanding VR‐induced symptoms and effects (VRISE) is pivotal to effective curriculum design. To compare self‐reported VRISE across different VR controller types, the study included 199 responses from students aged 18–54, enrolled in visceral anatomy or neuroanatomy ...
Sharmeen Adnan, Amanda C. Benson, Junhua Xiao   +2 more
wiley   +1 more source

Self‐ and Caregiver‐Reported Choice‐Making in Autistic Adults: Development and Validation of the AASPIRE–Choices and Decisions Scale

Autism Research, EarlyView.
ABSTRACT Self‐determination has been assessed as an internal psychological construct. External factors may also affect self‐determination, but opportunities to make choices and decisions remain understudied. We developed and evaluated the AASPIRE‐Choices and Decisions Scale (AASPIRE‐CDS), a new measure of autistic adults' opportunities to make choices ...
So Yoon Kim, Kristen Gillespie‐Lynch, Steven K. Kapp, Liu‐Qin Yang, Anna “Furra” Wallington, Dora M. Raymaker, Ian Moura, Katherine McDonald, Joelle Maslak, Rachel Kripke‐Ludwig, Andrea Joyce, Willi Horner‐Johnson, Emanuel Frowner, Mary Baker‐Ericzén, Christina Nicolaidis   +14 more
wiley   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source