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An Efficient Score Test Integrated with Empirical Bayes for Genome-Wide Association Studies [PDF]

open access: yesFrontiers in Genetics, 2021
Many methods used in multi-locus genome-wide association studies (GWAS) have been developed to improve statistical power. However, most existing multi-locus methods are not quicker than single-locus methods.
Jing Xiao   +3 more
doaj   +2 more sources

A Semiparametric Approach to Test for the Presence of INAR: Simulations and Empirical Applications

open access: yesMathematics, 2022
The present paper explores the application of bootstrap methods in testing for serial dependence in observed driven Integer-AutoRegressive (models) considering Poisson arrivals (P-INAR).
Lucio Palazzo, Riccardo Ievoli
doaj   +1 more source

Homogeneity Test of Many-to-One Relative Risk Ratios in Unilateral and Bilateral Data with Multiple Groups

open access: yesAxioms, 2023
In medical clinical studies, we often encounter paired organs’ unilateral or bilateral data. For bilateral data, there exists an intraclass correlation between paired organs.
Yuxin Li, Zhiming Li, Keyi Mou
doaj   +1 more source

Statistical Inference for Odds Ratio of Two Proportions in Bilateral Correlated Data

open access: yesAxioms, 2022
Bilateral correlated data frequently arise in medical clinical studies such as otolaryngology and ophthalmology. Based on an equal correlation coefficient model, this paper mainly aimed to investigate the statistical inference for the odds ratio of two ...
Zhiming Li, Changxing Ma
doaj   +1 more source

Association Testing of a Group of Genetic Markers Based on Next-Generation Sequencing Data and Continuous Response Using a Linear Model Framework

open access: yesMathematics, 2023
Association testing has been widely used to study the relationship between phenotypes and genetic variants. Most testing methods are based on genotypes. To avoid genotype calling and directly test on next-generation sequencing (NGS) data, sequencing data-
Zheng Xu
doaj   +1 more source

Evaluating the Goodness of Fit of Generalized Nakagami Distribution

open access: yesCumhuriyet Science Journal, 2023
The Generalized Nakagami distribution is a popular distribution in wireless communication. This distribution includes the Nakagami distribution as a special case.
Deniz Özonur
doaj   +1 more source

How to use χ2 test correctly——the score test and the implementation of SAS software

open access: yesSichuan jingshen weisheng, 2021
The purpose of this article was to introduce the score test and the SAS implementation. Concretely, there were five common forms of the score test statistics, namely the general score test statistic,the robust score test statistic,the residual score test
Hu Chunyan, Hu Liangping
doaj   +1 more source

Identifying Differentially Expressed Genes of Zero Inflated Single Cell RNA Sequencing Data Using Mixed Model Score Tests

open access: yesFrontiers in Genetics, 2021
Single cell RNA sequencing (scRNA-seq) allows quantitative measurement and comparison of gene expression at the resolution of single cells. Ignoring the batch effects and zero inflation of scRNA-seq data, many proposed differentially expressed (DE ...
Zhiqiang He   +3 more
doaj   +1 more source

A Novel Approach Integrating Hierarchical Clustering and Weighted Combination for Association Study of Multiple Phenotypes and a Genetic Variant

open access: yesFrontiers in Genetics, 2021
As a pivotal research tool, genome-wide association study has successfully identified numerous genetic variants underlying distinct diseases. However, these identified genetic variants only explain a small proportion of the phenotypic variation for ...
Liwan Fu   +5 more
doaj   +1 more source

A study of the score test in discrimination poisson and zero-inflated poisson models - doi: 10.4025/actascitechnol.v35i2.15071

open access: yesActa Scientiarum: Technology, 2013
In many experimental situations the sample may present excess zero observations and generally are used probabilistic models for zero inflated to represent them.
Vanessa Siqueira Peres da Silva   +2 more
doaj   +1 more source

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