Results 111 to 120 of about 8,292 (286)
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
The Saudi Journal of Gastroenterology, 2010 Wandering spleen is a rare condition defined as a mobile spleen only attached with its pedicle. It can be complicated by a volvulus, which is a surgical abdominal emergency.
El Bouhaddouti Hicham +8 more
doaj
Advanced Science, EarlyView.A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo +8 more
wiley +1 more source
Advanced Science, EarlyView.This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren +5 more
wiley +1 more source
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Obstrucción intestinal secundaria a vólvulo espléndico en un paciente pediátrico
Acta Médica Costarricense, 2005 La torsión de un bazo errante es rara. La forma de presentación varia desde dolor abdominal intermitente hasta un cuadro de abdomen agudo. Se presenta un caso clínico de un paciente pediátrico con obstrucción intestinal secundaria a la torsión de un bazo
Juan Pablo Murillo-Ortiz +1 more
doaj
Histological atlas of Florida Surgeonfish (Acanthuridae) [PDF]
, 2003 This histological atlas focuses on A. coeruleus and includes major organs and tissues. Particularly note the stomach tissues of both species, which illustrate the difference in digestive strategies of the Carribbean Acanthurids.
Francis-Floyd, Ruth +2 more
core
Wandering spleen presenting as gastric mass: A rare case [PDF]
Wandering or ectopic spleen is a rare condition in which spleen is located outside its normal location. Wandering spleen is an incidental finding with a reported incidence of <0.2%, fewer than 500 cases reported worldwide in literature. It presents as
Bhatia, Varsha Omprakash +2 more
core +2 more sources
Advanced Science, EarlyView.A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang +7 more
wiley +1 more source
A Rare Case of Splenic Torsion with Sigmoid Volvulus in a 14-Year-Old Girl
Acta Medica Iranica, 2016 Wandering spleen is an uncommon entity in adults and has been described only rarely with sigmoid volvulus, that rarely affects children and adolescents.
Hamid Ahmadi +1 more
doaj