Results 91 to 100 of about 25,597 (262)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Le Monde’s Coverage of Ukraine Amid the War: Themes and Issues
Актуальні питання масової комунікаціїThis article examines trends in Le Monde’s coverage of events in Ukraine and their global implications during Russia’s full-scale invasion of Ukraine.
Nataliia Zhelihovska, Maryna Hrytsaiko
doaj +1 more source
Panorama's coverage of 9/11 and the 'War on Terror' [PDF]
, 2010 The BBC's 'flagship' current affairs series Panorama backed away from reporting on the 9-11 attacks despite having a senior reporter with relevant expertise in the area. Subsequent coverage lacked investigative depth, recycled commonplace analogies with Hollywood films and drew unfounded links between the 9-11 leader Mohamed Atta and Iraq. This chapter
openaire
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
War correspondents reporting from conflictridden parts of the world
Хабаршы Журналистика сериясы, 2020 This article analyses the concept of objectivity is central to all forms of journalism, although its role in traditional war reporting has been a subject of complex and continuous debate.
Мысаева К. +1 more
doaj
The German press coverage on France after World War II [PDF]
Conflict & Communication Online, 2004 How is the continuing reconciliation process between the former "hereditary enemies" Germany and France reflected in German daily newspapers between 1946 and 1970?
Susanne Jaeger
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source