Results 91 to 100 of about 26,656 (261)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Peculiarities of pension coverage for disabled war veteran and their employment in Tambov Region in 40s and 50s of the 20th century

Вестник Тамбовского университета. Серия: Гуманитарные науки
The study of certain aspects of social adaptation and support, pension coverage and employment of disabled veterans of the Great Patriotic War allows us to clarify the peculiarities of post-war society development, development trajectories of the ...
P. P. Shcherbinin
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Digital war diaries: Witnessing the 2022 Russian War against Ukraine

Memory, Mind & Media
Digital media have changed the ways people mobilise and act collectively in times of crisis. During the Russian aggression against Ukraine, they have been at the forefront of war coverage giving users the possibility to share experiences of wartime ...
Svitlana Kot, Alina Mozolevska, Olha Polishchuk   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

“Spain is fighting for us”. Representations of the Spanish Civil War by the German left in exil

Diacronie. Studi di Storia Contemporanea, 2011
In this article, the press coverage of the Spanish Civil War by four German exile papers will be studied, raising the questions why the German left in exile was so much concerned with the conflict and how they connected the events in Spain with their own
Claudia Roesch is a junior researcher at the Department of History of University of Münster, Germany, working in the Emmy Noether Research Group “Family Values and Social Change- The US American Family in the 20th Century“ on a project about Mexican immigrant families. She has received her master’s degree at Humboldt-University of Berlin in 2009 with a master thesis: „Spanien kämpft für uns – Die Bedeutung des Spanischen Bürgerkriegs für die deutsche Linke im Exil 1936-1939“ [Spain is fighting for us – the significance of the Spanish Civil War for the German left in exile]. Research interests are studies of modernism, migration and exile history in an Ibero-American realm. URL: < http://www.uni-muenster.de/Geschichte/hist-sem/NwG-ZG/Mitarbeiter/croesch/index.html >
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

“Spectacle of Broken Cities and Broken Lives”

Medien & Zeit
This paper examines how the Spanish Civil War (1936–1939) was portrayed in the United States through innovative media forms. By conducting a qualitative content analysis of news outlets of Time Inc, the study investigates how photography, radio, and ...
Jakob Irler
doaj