Results 131 to 140 of about 2,670,639 (286)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Care under attack: a qualitative study of healthcare system disruption and health worker resilience during airstrikes on Lebanon. [PDF]

BMJ Glob Health
Al-Hajj S, Nassereldine R, Srour N, Bauer ME, Poole D, Issa I, Zurayk R, Mowafi H.   +7 more
europepmc   +1 more source

Zemljovid ratnog izvješćivanja

Medijska istraživanja : znanstveno-stručni časopis za novinarstvo i medije, 2004
Media coverage of the recent war in Iraq has become a subject of quite a bit of public discussion globally. Comparing this war with the Gulf War of 1990-91, there are differences in the ways in which reporting was done. Propaganda in the classical sense can be defined as “a deliberate and systematic attempt to shape perceptions, manipulate cognitions ...
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Medication access barriers and perceived health consequences in post-war Syria: a cross-sectional study in Homs. [PDF]

Glob Health Action
Al-Deeb R, Nasra AB, Aldakak MA, Muhrat B, Almansour S, Auf I, Almohammad H, Naimah F, Hajjo A, Al-Sebai N, Keshe M.   +10 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Advancing conflict research and response through satellite-derived data. [PDF]

Nature
Sticher V, Bara C, Kotajoki J, Bromley L, Crevoisier T, Dalsasso E, Dietrich O, Donnay K, Dorm F, Fiol M, Li X, Naghizadeh MH, Scher C, Van Den Hoek J, Schindler K, Tuia D, Wegner JD.   +16 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Preparing residents and fellows for armed conflict and war settings: a scoping review protocol of educational programmes. [PDF]

BMJ Open
Obeid R, Bou Melhem A, El Zein O, Abourjeili J, Assi C, El Bcherawi N, El Khoury M, Maroun P, Msheik-El Khoury F.   +8 more
europepmc   +1 more source