Results 141 to 150 of about 2,670,639 (286)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Impact of Russian invasion on radiation therapy capacity in Ukraine: a national survey study. [PDF]

BMJ Glob Health
Shepil Z, Buryk V, Zelinskyi R, Stadnyk L, Lozko Y, Brovchuk S, Mytsak L, Romalis Y, Bhatia R, Suchowerska N, Iakovenko V, Kizub D, Melnitchouk N, Kovalchuk N.   +13 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Act now: strengthening critical care readiness in fragile health systems during war and disasters. [PDF]

Crit Care
Elmi AH.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Suicides, suicide attempts and suicidal ideation among children and young people exposed to war: a scoping review. [PDF]

BMJ Open
Silwal S, Westerlund M, Wan Mohd Yunus WMA, Jaakola-Siimes S, Klomek AB, Sourander A.   +5 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Psychiatric outcomes in the first two years after the October 7 attacks: a systematic review of posttraumatic stress, anxiety, depression, and addiction-related outcomes. [PDF]

Front Psychiatry
Cohen M, Levitin MD, Gliksberg O, Levine E, Dvir T, Mikulincer M.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Maternal and perinatal outcomes during successive and overlapping crises in Ukraine, 2019-2024: a nationwide population-based ecological study. [PDF]

Lancet Reg Health Eur
Mogilevkina I, Marichereda V, Khadginova N, Southall D, Dobryanskyy D.   +4 more
europepmc   +1 more source