Results 141 to 150 of about 157,233 (338)

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source

"Die Traumereien einiger kunstliebender Klosterbruder...". Zur Situation der Kulturwissenschaftlichen Bibliothek Warburg zwischen 1929 und 1933 [PDF]

, 2000
Lucas Burkart
openalex   +1 more source

Microwave‐Activated Bacterial Biorobot for Multimodal Cancer Therapy

Advanced Science, EarlyView.
An Escherichia coli bacterial biorobot is engineered for localized microwave activation in cancer therapy. Upon activation at tumor sites, the biorobot releases glucose oxidase, inducing tumor cell death via glucose depletion and H2O2 generation catalyzed by Cu2O.
Huilan Zhuang, Yongjian Zhang, Yajuan Fu, Dangjin Ke, Qi Chen, Sijie Shao, Panpan Xue, Yuanchun Chen, Xuemei Zeng, Shuangqian Yan   +9 more
wiley   +1 more source

The Duchess’s Jewels

Incontri: Rivista Europea di Studi Italiani
Le gioie della duchessa: due inventari inediti di Lucrezia Borgia Questo articolo presenta la trascrizione completa integrata di commento di due inventari di gioie di Lucrezia Borgia d’Este (1480-1519), datati 20 aprile 1515 e finora passati ...
Carlotta Gonzi
doaj   +1 more source

Reviewing the structure and function of the scorpion's hepatopancreas [PDF]

Arthropods, 2012
During a long-terms study of scorpions, it was possible to follow changes taking place in the mass, water and lipid content of the hepatopancreas in freshly caught Scorpio maurus fuscus.
M.R. Warburg
doaj  

A case associated with Walker Warburg syndrome phenotype and homozygous pericentric inversion 9: coincidental finding or aetiological factor? [PDF]

, 2000
M. Zenker, H. G. Dörr
openalex   +1 more source

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source

Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression

Advanced Science, EarlyView.
In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han, Qi Jia, Guangjian Bai, Zhao Li, Jin Zeng, Zhenhua Wang, Jing Zhang, Jiashi Cao, Baoquan Xin, Yonggang Liu, Jingyu Shen, Lining Wang, Xing Huang, Chunlei Zhang, Kai Tong, Fenglei Dai, Yajie Zhang, Weina Zhu, Songyi Cheng, Yuanming Chen, Xinghai Yang, Guanghui Chen, Zhenhua Zhou, Yong Ma, Weibo Liu, Ting Wang, Tielong Liu   +26 more
wiley   +1 more source

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis [PDF]

, 2002
Huasheng Lu, Robert A. Forbes, Ajay Verma   +2 more
openalex   +1 more source

One‐Step Tunable MoS2 with Enhanced Zn2+ Diffusion for High‐Energy Zinc‐Ion Hybrid Capacitors

Advanced Science, EarlyView.
A one‐step, scalable method introduces ethylene glycol into MoS2 layers, expanding the interlayer distance from 0.617 to 0.948 nm. This modification enhances the diffusion of hydrated Zn2+ ions, significantly improving charge‐discharge kinetics. Abstract Zinc‐ion hybrid capacitors (ZIHCs) offer a promising solution for large‐scale energy storage ...
Harshitha B. Tyagaraj, Vikram Mahamiya, Supriya J. Marje, Gagankumar Sakleshpur Kumar, Shalmali R. Burse, Swapnil R Patil, Ebrahim Al Hajri, Nilesh R. Chodankar, Yun Suk Huh, Young Kyu Han   +9 more
wiley   +1 more source