Warburg effect: cancer cells metabolism [PDF]
, 2011 Prva istraživanja energetskog metabolizma tumora provodila su se 1922. godine u laboratoriju Otto Warburga. Warburg je ustanovio specifičan metabolizam stanica raka čija je karakteristika prijelaz s respiracije na fermentaciju - nazvan je Warburg-ov ...
Križnik, Bojana
core +2 more sources
Limits of aerobic metabolism in cancer cells [PDF]
, 2017 Cancer cells exhibit high rates of glycolysis and glutaminolysis. Glycolysis can provide energy and glutaminolysis can provide carbon for anaplerosis and reductive carboxylation to citrate.
Fernandez-de-Cossio-Diaz, Jorge +1 more
core +3 more sources
Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]
, 2011 Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez +2 more
core +5 more sources
Bayesian Metric Learning for Uncertainty Quantification in Image Retrieval [PDF]
arXiv, 2023 We propose the first Bayesian encoder for metric learning. Rather than relying on neural amortization as done in prior works, we learn a distribution over the network weights with the Laplace Approximation. We actualize this by first proving that the contrastive loss is a valid log-posterior.
arxiv
Variations of petrophysical properties and spectral induced polarization in response to drainage and imbibition: a study on a correlated random tube network [PDF]
Geophysical Journal International (2017) ggx474, 2017 We implement a procedure to simulate the drainage and imbibition in random, two-dimensional, square networks. We compute the resistivity index, the relative permeability, and the characteristic lengths of a correlated network at various saturation states, under the assumption that the surface conductivity can be neglected.
arxiv +1 more source
Modeling cancer metabolism on a genome scale [PDF]
, 2015 Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton +8 more
core +1 more source
Bayesian Triplet Loss: Uncertainty Quantification in Image Retrieval [PDF]
2021 ICCV, 2020 Uncertainty quantification in image retrieval is crucial for downstream decisions, yet it remains a challenging and largely unexplored problem. Current methods for estimating uncertainties are poorly calibrated, computationally expensive, or based on heuristics.
arxiv
Mixed-valence compounds as polarizing agents for Overhauser dynamic nuclear polarization in solids [PDF]
arXiv, 2021 In this paper we investigate a novel set of polarizing agents -- mixed-valence compounds -- by theoretical and experimental methods and demonstrate their performance in high-field Dynamic Nuclear Polarization (DNP) experiments in the solid state. Mixed-valence compounds constitute a group of molecules, in which molecular mobility persists even in ...
arxiv
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation [PDF]
, 2019 Regulation of the energetic metabolism occurs fundamentally at the cellular level, so analytical strategies must aim to attain single cell resolution to fully embrace its inherent complexity.
Behrensen, C. +3 more
core +1 more source
Overflow metabolism originates from growth optimization and cell heterogeneity [PDF]
arXiv, 2023 A classic problem in metabolism is that fast-proliferating cells use seemingly wasteful fermentation for energy biogenesis in the presence of sufficient oxygen. This counterintuitive phenomenon, known as overflow metabolism or the Warburg effect, is universal across various organisms.
arxiv