Results 31 to 40 of about 404,362 (163)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Other title: Kansas Warm Homes Conservation Kit; Other title: Warm Homes Conservation Kit

, 2005
Includes a message from Kansas Governor Kathleen Sebelius. "This material was prepared with the support of the U.S. Department of Energy (DOE) Grant No. DE-FG48-02R830102.
Kansas Warm Homes Project.
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GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Prolotherapy at Multifidus Muscle versus Mechanical Needling and Sterile Water Injection in Lumbar Spinal Stenosis

, 2023
Carl PC Chen,1 Areerat Suputtitada2,3 1Department of Physical Medicine & Rehabilitation, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan City, Taiwan; 2Department of Rehabilitation Medicine, Faculty of ...
Suputtitada A, Chen CPC
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Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Final Report, Wind Power Resource Assessment on the Warm Springs Reservation Tribal Lands, Report No. DOE/GO/12103

, 2007
This report concludes a five-year assessment of wind energy potential on the Confederated Tribes of Warm Springs Reservation of Oregon ...
Jim Manion, Warm Springs Power & Water Enterprises, Engineering, HDR, Dr. Stel Walker, Oregon State University, David McClain, McClain & Associates   +3 more
core   +1 more source

Northern Hemisphere Glaciation during the Globally Warm Early Late Pliocene [PDF]

, 2013
The early Late Pliocene (3.6 to ∼3.0 million years ago) is the last extended interval in Earth's history when atmospheric CO₂ concentrations were comparable to today's and global climate was warmer.
Head, Martin J., Head, M, Louwye, S., Van Renterghem, Cédéric, Stijn De Schepper (496614), Karl, Fabian, Fabian, K., Naafs, B David A, Naafs, B. David A., Karl Fabian (496621), Jeroen Groeneveld, Stephen Louwye (496620), De Schepper, S., Jan Hennissen, B. David A Naafs (496616), Fabian, Karl, Hennissen, Jan, Louwye, Stephen, Groeneveld, J, De Schepper, Stijn, Cédéric Van Renterghem, Jan Hennissen (496618), Naafs, B D A, Renterghem, Cédéric, Stephen Louwye, Head, Martin, Van Renterghem, C., Martin J Head, Jeroen Groeneveld (496615), Hennissen, J., B David A Naafs, Stijn De Schepper, DeSchepper, Stijn, Karl Fabian, Naafs, B.D.A., Groeneveld, Jeroen, Groeneveld, J., Martin J. Head (496619), Head, M.J., Cédéric Van Renterghem (496617)   +39 more
core   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Experimental and numerical analysis of the cyclic behaviour of RC beam-column connections with plain reinforcing bars [PDF]

, 2012
The information available in the literature about the cyclic behaviour of reinforced concrete elements with plain reinforcing bars is scarce. As a consequence, the influence of bar slippage in elements with plain bars is not yet comprehensively ...
Costa, A., Fernandes, C., Melo, J., Varum, H.   +3 more
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