Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi +18 more
wiley +1 more source
Analysis on factors controlling organic matter enrichment in marine-terrestrial transitional shale of Member 1, Upper Carboniferous Keluke Formation, Huaitoutala area, east of northern margin of Qaidam Basin, China. [PDF]
Lai T +6 more
europepmc +1 more source
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng +6 more
wiley +1 more source
Comment on 'Discreteness Effects in Simulations of Hot/Warm Dark Matter' by J. Wang & S.D.M. White
Adrian L. Melott
openalex +1 more source
Warm Dark Matter: Clues to Primordial Phase Density from the Structure of Galaxy Halos [PDF]
Craig J. Hogan
openalex +1 more source
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li +9 more
wiley +1 more source
Influence of temperature on selenium mobility under contrasting redox conditions: a sediment flow-through reactor experiment. [PDF]
Laberge-Carignan A +3 more
europepmc +1 more source
X-ray line signal from decaying axino warm dark matter
Ki-Young Choi, Osamu Seto
openalex +1 more source
Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways
Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate‐based codes in the cortex. This transformation highlights a robust neural strategy for turning complex acoustic input into coherent perception across the ...
Alexa Buck +7 more
wiley +1 more source

