Results 171 to 180 of about 417,071 (324)

Towards the Chalonge 16th Paris Cosmology Colloquium 2012: Highlights and Conclusions of the Chalonge 15th Paris Cosmology Colloquium 2011

open access: yes, 2012
The Chalonge 15th Paris Cosmology Colloquium 2011 was held on 20-22 July in the historic Paris Observatory's Perrault building, in the Chalonge School spirit combining real cosmological/astrophysical data and hard theory predictive approach connected to ...
de Vega, H. J.   +2 more
core   +3 more sources

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene

open access: yesAdvanced Science, EarlyView.
Exposure to PTFE (teflon), a commonly used microplastic in non‐stick cookware, significantly reduces sperm quality in both humans and mice. Specifically, PTFE induces the disruption of sperm cytoskeleton and F‐actin assembly through targeting SKAP2 in haploid spermatid.
Shiming Gan   +15 more
wiley   +1 more source

COZMIC. III. Cosmological Zoom-in Simulations of Self-interacting Dark Matter with Suppressed Initial Conditions

open access: yesThe Astrophysical Journal
We present eight cosmological dark matter (DM)-only zoom-in simulations of a Milky Way–like system that include suppression of the linear matter power spectrum P ( k ), and/or velocity-dependent DM self-interactions, as the third installment of the ...
Ethan O. Nadler   +5 more
doaj   +1 more source

Structure formation in warm dark matter cosmologies

open access: yes, 2015
The nature of dark matter constitutes one of the biggest questions in physics, cosmology and astronomy. This thesis explores dark matter hypothesized models, with a focus on warm dark matter models, from both theoretical and numerical simulations perspectives, with the purpose of constraining the dark matter particle candidates.
openaire   +2 more sources

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

open access: yesAdvanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho   +12 more
wiley   +1 more source

The haloes of bright satellite galaxies in a warm dark matter universe [PDF]

open access: bronze, 2012
Mark R. Lovell   +9 more
openalex   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

open access: yesAdvanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez   +20 more
wiley   +1 more source

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

open access: yesAdvanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan   +10 more
wiley   +1 more source

Introducing the DREAMS Project: DaRk mattEr and Astrophysics with Machine Learning and Simulations

open access: yesThe Astrophysical Journal
We introduce the DaRk mattEr and Astrophysics with Machine learning and Simulations (DREAMS) project, an innovative approach to understanding the astrophysical implications of alternative dark matter (DM) models and their effects on galaxy formation and ...
Jonah C. Rose   +29 more
doaj   +1 more source

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