Results 261 to 270 of about 428,876 (333)

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

open access: yesAdvanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang   +13 more
wiley   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

open access: yesAdvanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong   +22 more
wiley   +1 more source

Stress‐Induced Melting Controlled Failure Mechanisms of Methane Hydrate

open access: yesAdvanced Science, EarlyView.
We study methane hydrate via nanoindentation and nuclear magnetic resonance (NMR), finding its regional melting and mechanical properties, challenging existing views on hydrogen‐bonded crystals. Abstract Methane hydrate, a kind of nonstoichiometric crystalline, attracted worldwide attentions as a promising substitute energy. Its Dissociation is thought
Yanlong Li   +9 more
wiley   +1 more source

Illuminating growth: Celebrating the life and legacy of Dr. Joanne Chory. [PDF]

open access: yesPlant Physiol
Brusslan J   +6 more
europepmc   +1 more source

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

open access: yesAdvanced Science, EarlyView.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt   +5 more
wiley   +1 more source

A CSF Background Suppression Scheme in Arterial Spin Labeling MRI. [PDF]

open access: yesNMR Biomed
Hu Z   +6 more
europepmc   +1 more source

Photoelectrochemical CO2‐to‐Formic Acid Conversions: Advances in Photoelectrode Designs and Scale‐Up Strategies

open access: yesAdvanced Energy Materials, EarlyView.
Schematic of a photoelectrochemical CO2‐to‐formic acid conversion. The outer circle highlights that the generated formic acid can be stored and later utilized as a fuel, while the emitted CO2 can be captured and recycled, ultimately contributing to a zero‐carbon emission cycle.
Bilawal Khan   +7 more
wiley   +1 more source

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