Results 121 to 130 of about 245,760 (237)

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

A Competitive Equilibrium for a Warm Glow Economy [PDF]

Despite a widespread interest in the warm glow model [Andreoni (1989,1990)], surprisingly most attention focused on the voluntary contribution equilibrium of the model, and only very little attention has been devoted to the competitive equilibrium.
Nizar Allouch
core  

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

The effectiveness of deep dry needling combined with neural mobilisation in patients with sciatic hyperalgesia: a case report

Introduction Sciatic hyperalgesia is a rare chronic pain condition caused by sciatic nerve constriction at focal areas extending from the lower back to the foot.
Praveen Kumar Kandakurti, Sukumar Shanmugam, Satheeskumar Durairaj   +2 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

LLM‐Based Multimodal Robotic Endoscope Control Framework for Enhancing Human–Robot Interaction in Minimally Invasive Surgery

Advanced Intelligent Systems, EarlyView.
An large language model‐powered multimodal framework is developed for robotic endoscope control. It integrates speech recognition and real‐time instrument tracking, achieving 89.47% command accuracy with ~1s latency for natural human–robot interaction in minimally invasive surgery.
Yisen Huang, Wing Yin Ng, Qi Dou, Xixin Wu, Shannon Melissa Chan, Yunhui Liu, Philip Wai Yan Chiu, Zheng Li   +7 more
wiley   +1 more source

A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li, Yujie Chen, Rongsu Huang, Min Xia, Chao Mi, Yuan Tian, Peiwen Guo, Taotao Jin, Shilei Hao, Hua Feng, Yujie Chen, Zhi Chen   +11 more
wiley   +1 more source

Seasonal Fluctuations of Plastochromanol‐8 and α‐Tocopherol Amounts in the Leaves of Cecropia Trees

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plastochromanol‐8 (PC‐8) is a homologue of γ‐tocotrienol with a longer side chain (eight instead of three isoprene units) and therefore also a representative of the tocochromanol (vitamin E) group. PC‐8 has been determined in various plants and seeds, with Cecropia sp. leaves showing unusually high levels.
Rosalie Ormos, Jörg Rau, Walter Vetter
wiley   +1 more source

A new species of Lonchidiidae (Hybodontiformes) from the Late Jurassic of Brazil (Aliança Formation, Jatobá Basin)

The Anatomical Record, EarlyView.
Abstract The Aliança Formation (Jatobá Basin) represents lacustrine deposits formed in oxygenated waters that hosted a diverse fauna, including Hybodontiform sharks. Within this group, the Family Lonchidiidae comprises 11 valid genera, with Parvodus previously reported in Brazilian deposits from the Brejo Santo Formation (Araripe Basin, Late Jurassic ...
Larissa de Souza Ribeiro, Marco Aurélio Gallo de França   +1 more
wiley   +1 more source