Results 161 to 170 of about 481,746 (305)

Major volcanic eruptions episodically disrupted the continuity of polar warming through aerosol forcing. [PDF]

NPJ Clean Air
Swain B, Osprey S, Grainger RG, Song R, Vountas M.   +4 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Elevated CO₂ mitigated warming-enhanced carbon loss from northern peatland. [PDF]

Sci Adv
Zhou J, Quan Q, Huang W, Hanson PJ, Ricciuto D, Mayes MA, Griffiths NA, Salmon VG, Weber SE, Warren JM, Norby RJ, McPartland MY, Dusenge ME, Way D, Jiang L, Zhou Y, Xu H, Tao F, Shi X, Chen W, Zhang Y, Luo Y.   +21 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Evaluating Global Warming Potentials as Historical Temperature Proxies: an application of ACC2 Inverse Calculation [PDF]

Global Warming Potentials (GWPs) are evaluated as proxies of the historical temperature by applying them to convert historical CH4 and N2O emissions to equivalent CO2 emissions.
Michael Obersteiner, Richard S.J. Tol, Katsumasa Tanaka, Brian C. O'Neill, Dmitry Rokityanskiy   +4 more
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Projected Exposure of Canadian Children to Rare, High-Severity Heatwaves Under Continued Warming. [PDF]

Geohealth
Zaerpour M, Taleghanidoozdoozan S, Steele BJ, Hatami S, Xu LL, Papalexiou SM, Helldén D.   +6 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Precipitation Regulates Phenological Responses of Annual and Perennial Forbs to Warming and Degradation in an Alpine Meadow on the Qinghai-Xizang Plateau. [PDF]

Ecol Evol
Chen L, Cui S, Sun J, Lv W, Lv J, Yuan F, Zhou Y, Wang A, Wang S.   +8 more
europepmc   +1 more source