Results 31 to 40 of about 780,087 (224)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Boletín del Museo del Prado, 2014 Recent study of two panels in Philadelphia generally attributed to Rogier van der Weyden, the Crucifi xion with the Virgin and Saint John the Evangelist Mourning, indicated that the paintings, often considered an independent diptych, are actually a ...
Griet Steyaert, Mark S. Tucker
doaj
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
From the Washington Consensus to the Post-Washington Consensus: Retrospect and Prospect
Asian Development Review, 2003 The past two decades have witnessed major changes in the paradigm of international development assistance. During the 1980s the import-substitution industrialization strategy (ISI) advocating for government market interventions to promote large-scale ...
YUJIRO HAYAMI
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Into the Unknown: The 2024 Washington State Legislative Session & Beyond
California Journal of Politics and PolicyIn this paper, we discuss the political and budgetary landscape of Washington State. With consistent Democratic leadership—in the governor’s mansion and with respect to legislative priorities—the state has been able to advance a more liberal policy ...
Michael Artime +2 more
doaj +1 more source
International Journal of Nanomedicine, 2023 Joshua Ghofrani,1,2 Allan Bowen,2 Jie Chen,2 Preethi Bala Balakrishnan,2 Allison B Powell,1,2 Kondareddy Cherukula,2 Conrad Russell Y Cruz,2,3 R Brad Jones,4 Rebecca M Lynch,5 Elizabeth E Sweeney,2,6 Rohan Fernandes1,2,7 1The Institute for Biomedical ...
Ghofrani J +10 more
doaj
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source