Results 41 to 50 of about 780,087 (224)
Researchers at the National Institutes of Health, Bethesda, MD; Children’s National Medical Center; and George Washington University, Washington, DC present 7 patients with Muenke syndrome complicated by epilepsy.
J Gordon Millichap
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Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Cognitive and Speech Deficits with Opsoclonus-Myoclonus
Thirteen patients, aged 1.7 to 16 years, with opsoclonus-myoclonus syndrome were evaluated for neuropsychological, psychosocial and adaptive function at the Children’s National Medical Center, George Washington University, Washington, DC.
J Gordon Millichap
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NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
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117th Annual Meeting, Medical Library Association, Inc., Seattle, WA, May 26–31, 2017
The Medical Library Association (MLA) held its 117th annual meeting in Seattle, Washington, May 26–31, 2017, at the Washington State Convention Center. The meeting theme was “Dream, Dare, Do.”
Nicole Mitchell
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Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
El estudio reciente de dos tablas conservadas en Filadelfi a y comúnmente atribuidas a Rogier van der Weyden, la Crucifi xión con la Virgen y san Juan Evangelista dolientes, indicó que las pinturas, a menudo consideradas un díptico independiente, en ...
Mark S. Tucker, Griet Steyaert
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4D Thermo-Responsive Smart hiPSC-CM Cardiac Construct for Myocardial Cell Therapy
Sung Yun Hann,1,* Haitao Cui,1,* Timothy Esworthy,1 Lijie Grace Zhang1– 4 1Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, 20052, USA; 2Department of Electrical and Computer Engineering, The ...
Hann SY, Cui H, Esworthy T, Zhang LG
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Development Lessons for Asia from Non-Asian Countries
The disappointments of the Washington Consensus have led to the search for a new paradigm to replace it. The chief failing of the Washington Consensus was that it represented an approach based on “rules of thumb.” As such it was not well grounded either ...
Dani Rodrik
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