Results 141 to 150 of about 623,412 (262)

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

Quantitative rapid image-based method for coronary artery blood flow and wall shear stress extraction. [PDF]

Front Bioeng Biotechnol
Ju Y, Tansu N, Psaltis PJ, Ghayesh MH.
europepmc   +1 more source

Biopsy of Iris and Anterior Chamber Tumours: Fine Needle, Minimally Invasive and Excision Techniques ‐ Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Several benign, inflammatory and malignant lesions can present as iris or anterior chamber masses, including iris naevi, cysts, adenomas, leiomyomas, nodules, vascular tumours, melanomas, metastases, as well as iris and pigment epithelium adenocarcinomas. Fortunately, benign iris lesions are much more common than malignant tumours and many can
Charles N. J. McGhee, Joevy Z. Lim, Peter W. Hadden, Jie Zhang   +3 more
wiley   +1 more source

The Influence of Hydroxyl Group on Nerve Excitability Blockade by Limonene and Its Hydroxylated Metabolites, Perillyl Alcohol and Carveol. [PDF]

Molecules
Amâncio LC, Sousa-Silva E, Cardeal-Dos-Santos AN, Rabelo ISM, Saraiva GPA, Cardoso-Teixeira AC, Moreira-Gomes MD, Cruz Freire JED, Coelho-de-Souza AN, Ferreira-da-Silva FW, Silva-Alves KSD, Leal-Cardoso JH.   +11 more
europepmc   +1 more source

Pharmacological and non‐pharmacological interventions for managing sleep disorders in children with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
xxxxxx Aim To systematically review the effectiveness, safety, and economic evidence of pharmacological and non‐pharmacological interventions for sleep disorders in children with cerebral palsy (CP). Method Databases including MEDLINE, Embase, CENTRAL (the Cochrane Library), International Clinical Trials Registry Platform of the World Health ...
Nishant Jaiswal, Lizzie Fisher, Giorgio Ciminata, Ryan Mulholland, Anna Noel‐Storr, Lesley Nutton, Valerie Orr, Paul Eunson, Nicola J. Cooper, Alex Sutton, Olivia Wu, Terry Quinn   +11 more
wiley   +1 more source

The Use of Citicoline in Ophthalmology: A systematic review. [PDF]

Beyoglu Eye J
Icel E, Akmaz O.
europepmc   +1 more source

Energy spectrum-based correction of washout rates in dual-isotope ¹²³I-BMIPP/²⁰¹Tl imaging. [PDF]

Ann Nucl Med
Nakajima K, Makida S, Okamura M, Kawashiri MA, Shibutani T.   +4 more
europepmc   +1 more source

Brewing Anxiety: Caffeine-Induced Thigmotaxis in Zebrafish Larvae. [PDF]

Brain Behav
ABSTRACT Background Thigmotaxis, or edge preference, is widely used as a measure of anxiety in vertebrate model systems. However, variability in this behavior limits its utility as a scalable measure for anxiolytic drug discovery. In the current study, we examine caffeine‐induced thigmotaxis, using 5‐day‐old zebrafish larvae as a model system.
Rai R, Del Rosario Hernandez T, Creton R.   +2 more
europepmc   +2 more sources

Cardiorenal Mortality and Safety Outcomes of GLP‐1 Receptor Agonists in Type 2 Diabetes With BMI Below 27 kg/m2: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Cardiorenal evidence for glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) derives mainly from trials in overweight or obesity; data in adults with Type 2 diabetes (T2D) and body mass index (BMI) below 27 kg/m2 are limited. Materials and Methods We emulated a target trial in the TriNetX US Collaborative Network (index dates 2020 to ...
Shao‐Chia Chen, Yu‐Nan Huang, Pei‐Yun Li, Jo‐Ching Chen, Gideon Meyerowitz‐Katz, Shun‐Fa Yang, Pen‐Hua Su   +6 more
wiley   +1 more source

Understanding volatile capture devices and their role in improving the sustainability of veterinary anaesthesia. [PDF]

Vet Rec
Ryan AC.
europepmc   +1 more source