Results 151 to 160 of about 18,795 (241)

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Receptor subtype distribution from PET occupancy studies: Novel analysis of maximum occupancy images using a selective drug and a non-selective tracer. [PDF]

J Cereb Blood Flow Metab
Kim SJ, Ibrahimy A, Constantinescu CC, Hoye J, Searle GE, Slifstein M, Rabiner EA, Morris ED.   +7 more
europepmc   +1 more source

Study of prompt gamma and neutron emission for real‐time range verification in proton and carbon‐ion therapy

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Accurate range verification is crucial in hadrontherapy to fully exploit the ballistic advantages of charged particles and prevent damage to healthy tissues. Among the proposed approaches, prompt gamma imaging (PGI) has emerged as an effective technique for real‐time monitoring, but its performance is limited by the intense neutron ...
Emma Sofia Bellotti, Davide Mazzucconi, Davide Bortot, Andrea Pola, Carlo Fiorini, Korbinian Urban, Stefano Agosteo   +6 more
wiley   +1 more source

A novel <i>in vitro</i> dye-based flow visualization method for quantifying the neointimal healing response of aneurysm devices in endothelialized silicone models. [PDF]

Interv Neuroradiol
Dooley J, Cardinal KO.
europepmc   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

Multiplexed Fiber-Optic Fluorescence for Functional Monitoring of Perfused Hearts. [PDF]

Anal Chem
Qiu J, Waters E, Lupton E, Baark F, Wallabregue ALD, Conway SJ, Southworth R, Bergholt MS.   +7 more
europepmc   +1 more source

Efficacy and Safety of Pregabalin and Alpha‐Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open‐Label, Non‐Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6172-6183, July 2026.
ABSTRACT Aims To assess the efficacy and safety of alpha‐lipoic acid (ALA) and pregabalin, both as mono and combination therapy, for treating painful diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus, with the hypothesis that pregabalin monotherapy is non‐inferior to combination therapy.
Tae Jung Oh, Sang Soo Kim, Seung‐Hwan Lee, Hyuk‐Sang Kwon, Eun Sook Kim, Eun‐Jung Rhee, Hye Jin Yoo, Han Na Jang, Woo Je Lee, Eun Sook Kim, Sang Yong Kim, Gwanpyo Koh, Eun‐Gyoung Hong, Tae Sun Park, Jong Chul Won   +14 more
wiley   +1 more source

The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures. [PDF]

PLoS Biol
Rezaei A, Areshenkoff CN, Gale DJ, Oby ER, Smallwood J, Flanagan JR, Wammes JD, Gallivan JP.   +7 more
europepmc   +1 more source

Estimates of Spawning Stream Contributions to an Imperilled Bull Trout Metapopulation Utilizing Otolith Geochemistry and Redd Counts

Ecology of Freshwater Fish, Volume 35, Issue 3, July 2026.
ABSTRACT Migratory fish species have experienced substantial declines throughout aquatic habitats, but actions to manage and conserve migratory species require a better understanding of the relative contributions of local populations to the metapopulation.
Samuel L. Bourret, Jill M. Janak, Timothy J. Linley, Geoffrey A. McMichael   +3 more
wiley   +1 more source

Microtubule-driven cell shape changes and actomyosin flow synergize to position the centrosome. [PDF]

J Cell Biol
Schaeffer A, Buracco S, Gazzola M, Gelin M, Vianay B, de Pascalis C, Blanchoin L, Théry M.   +7 more
europepmc   +1 more source