Results 171 to 180 of about 18,795 (241)

DNA-based characterization of primary hepatic MALT lymphoma reveals a rare FAT3 missense variant and Hippo pathway activation: a case report and literature review. [PDF]

World J Surg Oncol
Zhang R, Zhang C, Bai Z, Zhang Y, Wei F, Zhang A.   +5 more
europepmc   +1 more source

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1485-1493, June 2026.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen, Deena L. Hadi, Daniel A. Todd, Preston K. Manwill, John R. White, Matthew E. Layton, Nadja B. Cech, Kenneth E. Thummel, Mary F. Paine   +8 more
wiley   +1 more source

Influence of Cooling Agents on the Arrhythmogenic and Autonomic Effects of Electronic Cigarettes in an in vivo Model. [PDF]

Circ Arrhythm Electrophysiol
Kucera C, Ramalingam AR, Raph SM, Paily R, Srivastava S, Lorkiewicz PK, Bhatnagar A, Nystoriak MA, Carll AP.   +8 more
europepmc   +1 more source

Safety, Pharmacokinetics, and Dose Recommendations for Nirmatrelvir/Ritonavir in Individuals with Mild to Moderate COVID‐19 and Severe Renal Impairment

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1604-1613, June 2026.
Patients with severe renal impairment and COVID‐19 are at high risk for severe disease and death. Nirmatrelvir/ritonavir, an antiviral therapy for COVID‐19, is eliminated by renal excretion and can accumulate in patients with severe renal impairment.
Jacqueline Gerhart, Candace R. Bramson, Michelle Goulding, Haihong Shi, Olayide Oladoyinbo, Phylinda L. S. Chan, Sunring Chime, Jennifer Hammond   +7 more
wiley   +1 more source

Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition. [PDF]

Nat Commun
Boscaini S, Bastiaanssen TFS, Moloney GM, Bergamo F, Zeraik L, O'Leary C, Ferri A, Irfan M, van der Rhee M, Lindemann TIF, Schneider E, Meyyappan AC, Harold KB, Long-Smith CM, Carbia C, O'Riordan KJ, de Alvarenga JFR, Tosi N, Del Rio D, Rosi A, Bresciani L, Mena P, Clarke G, Cryan JF.   +23 more
europepmc   +1 more source

Osteogenic Potential of a Three‐Phase Strontium‐ and Silicon‐Doped Tricalcium Silicate Cement on Dental Pulp Stem Cells: An In Vitro Study

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objective This study aimed to evaluate the osteogenic potential of a novel three‐phase cement composed of strontium‐doped hydroxyapatite (Sr‐HA), silicon‐doped hydroxyapatite (Si‐HA), and tricalcium silicate (C3S) on dental pulp stem cells (DPSCs) in vitro.
Nahid Nasrabadi, Ehsan Saburi, Hossein Bagheri, Atekeh Hosseinpour, Mahsa Ghorbani, Pooya Saeedi   +5 more
wiley   +1 more source

Effects of γ-Aminobutyric Acid (GABA) Supplementation on Symptoms, Quality of Life, Intestinal Permeability, Systemic Inflammation and Gut Microbiota in Patients with IBS-D: A Randomized, Double Blind, Placebo-Controlled, Crossover Pilot Study. [PDF]

Nutrients
Lambiase C, Cancelli L, Tedeschi R, Grosso A, Rettura F, Salemmo R, Bottari A, Filippini F, Salvadori S, Valdiserra G, Campigli L, Antonioli L, Fornai M, de Bortoli N, Bellini M.   +14 more
europepmc   +1 more source

Historical Contingency Drives Freshwater Microbial Community Assembly Across Successional Time

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using a 60‐day full‐factorial reciprocal transplant microcosm experiment, we quantified the relative contributions of historical contingency, environmental selection, and dispersal limitation to freshwater bacterial community assembly. We show a pronounced temporal shift from early dispersal‐driven assembly to late‐stage dominance of historical ...
Fenguo Zhang, Xiaoting Zhang, Dongqing Yan, Yufeng Jing, Yongji Wang   +4 more
wiley   +1 more source

Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the K_v4 Channel Modulator, NS5806. [PDF]

Pharmacol Res Perspect
Veale EL, Matthews PM, Rush AM, Stevens EB, Mathie A.   +4 more
europepmc   +1 more source

Microelectrode array scaled for human hippocampal slices

Epilepsia Open, Volume 11, Issue 3, Page 777-786, June 2026.
Abstract Objective Temporal lobe epilepsy (TLE) is characterized by recurrent seizures originating usually from the hippocampus, and approximately one‐third of TLE patients remain refractory to pharmacological interventions. Surgical resection offers a potential cure for refractory TLE cases, with approximately 70% achieving seizure freedom. Still, the
Anssi Pelkonen, Vera Lezhneva, Tomi Ryynänen, Joose Kreutzer, Valeriia Sitnikova, Mireia Gómez‐Budia, Adriana Della Pietra, Antonios Dougalis, Jenni Kyyriäinen, Mastaneh Torkamani‐Azar, Henri Eronen, Tuomas Rauramaa, Arto Immonen, Ville Leinonen, Alejandra Sierra, Reetta Kälviäinen, Tarja Malm   +16 more
wiley   +1 more source